Author

de Knegt RJ

November 4, 2015
The estimated future disease burden of hepatitis C virus in the Netherlands with different treatment paradigms
Summary Background & Aims Prevalence of hepatitis C virus (HCV) infection in the Netherlands is low (anti-HCV prevalence 0.22%). All-oral treatment with direct-acting antivirals (DAAs) is tolerable and effective but expensive. Our analysis projected the future HCV-related disease burden in the Netherlands by applying different treatment scenarios. Methods Using a modelling approach, the size of […]

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January 5, 2015
Strategies to manage hepatitis C virus (HCV) infection disease burden – volume 2
Summary The hepatitis C virus (HCV) epidemic was forecasted through 2030 for 15 countries, and the relative impact of two scenarios was considered: (i) increased treatment efficacy while holding the treated population constant and (ii) increased treatment efficacy and increased annual treated population. Increasing levels of diagnosis and treatment, in combination with improved treatment efficacy, […]

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January 5, 2015
The present and future disease burden of hepatitis C virus (HCV) infections with today’s treatment paradigm – volume 2
Summary Morbidity and mortality attributable to chronic hepatitis C virus (HCV) infection are increasing in many countries as the infected population ages. Models were developed for 15 countries to quantify and characterize the viremic population, as well as estimate the number of new infections and HCV related deaths from 2013 to 2030. Expert consensus was […]

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January 5, 2015
Historical epidemiology of hepatitis C virus (HCV) in select countries – volume 2
Summary Chronic hepatitis C virus (HCV) infection is a leading cause of liver related morbidity and mortality. In many countries, there is a lack of comprehensive epidemiological data that are crucial in implementing disease control measures as new treatment options become available. Published literature, unpublished data and expert consensus were used to determine key parameters, […]

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