Parkes J

August 7, 2014
Modelling the impact of improving screening and treatment of chronic hepatitis C virus infection on future hepatocellular carcinoma rates and liver-related mortality
Summary Background The societal, clinical and economic burden imposed by the complications of chronic hepatitis C virus (HCV) infection – including cirrhosis and hepatocellular carcinoma (HCC) – is expected to increase over the coming decades. However, new therapies may improve sustained virological response (SVR) rates and shorten treatment duration. This study aimed to estimate the […]

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May 5, 2014
Strategies to manage hepatitis C virus (HCV) disease burden
Summary The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis […]

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May 5, 2014
The present and future disease burden of hepatitis C virus (HCV) infection with today’s treatment paradigm
Summary The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modeling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, […]

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May 5, 2014
Historical epidemiology of hepatitis C virus (HCV) in selected countries
Summary Chronic infection with hepatitis C virus (HCV) is a leading indicator for liver disease. New treatment options are becoming available, and there is a need to characterize the epidemiology and disease burden of HCV. Data for prevalence, viremia, genotype, diagnosis and treatment were obtained through literature searches and expert consensus for 16 countries. For […]

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