In December 2021, the European Association for the Study of the Liver (EASL)–Lancet Commission on liver disease in Europe launched its first report, which highlighted an alarming increase in liver-related mortality in many European countries. The Commission proposed a roadmap for addressing the documented negative trends. However, quoting one of the accompanying Comment articles, “gaining consensus on what needs to be done is perhaps the easiest step. Implementing change will be much harder, with many vested interests, both professional and commercial, to overcome.” This Commission aimed to evaluate and advance the enactment of the previously proposed recommendations.