{"id":9163,"date":"2026-01-01T06:12:00","date_gmt":"2026-01-01T06:12:00","guid":{"rendered":"https:\/\/cdafound.org\/?p=9163"},"modified":"2026-05-31T17:05:45","modified_gmt":"2026-05-31T17:05:45","slug":"bulevirtide-for-chronic-hepatitis-delta-from-clinical-trials-to-real-life-data-an-expert-opinion-report","status":"publish","type":"post","link":"https:\/\/cdafound.org\/zh\/bulevirtide-for-chronic-hepatitis-delta-from-clinical-trials-to-real-life-data-an-expert-opinion-report\/","title":{"rendered":"\u5e03\u6d1b\u97e6\u80bd\u6cbb\u7597\u6162\u6027\u4e01\u578b\u809d\u708e\uff1a\u4ece\u4e34\u5e8a\u8bd5\u9a8c\u5230\u771f\u5b9e\u4e16\u754c\u6570\u636e\uff1a\u4e13\u5bb6\u610f\u89c1\u62a5\u544a"},"content":{"rendered":"<h2 class=\"wp-block-heading\">\u6982\u62ec<\/h2>\n\n\n\n<p>\u4e01\u578b\u809d\u708e\u75c5\u6bd2 (HDV) \u662f\u4e00\u79cd\u5c0f\u578b RNA \u75c5\u6bd2\uff0c\u5176\u5305\u819c\u9700\u8981\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f (HBsAg) \u624d\u80fd\u5f62\u6210\u3002\u76ee\u524d\u5df2\u53d1\u73b0 8 \u79cd\u57fa\u56e0\u578b\uff0c\u5176\u5e8f\u5217\u540c\u6e90\u6027\u8d85\u8fc7 80 \u4e2a %\uff0c\u4ee5\u53ca\u8bb8\u591a\u4e9a\u57fa\u56e0\u578b\u3002\u636e\u4f30\u8ba1\uff0c\u5168\u7403\u6162\u6027\u4e01\u578b\u809d\u708e (CHD) \u7684\u60a3\u75c5\u7387\u7ea6\u4e3a\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u4f8b\u7684 5 \u500d\uff0c\u76f8\u5f53\u4e8e 1500 \u4e07\u81f3 2000 \u4e07\u4eba\u3002HDV \u611f\u67d3\u7684\u8bca\u65ad\u4f9d\u636e\u662f\u662f\u5426\u5b58\u5728\u9488\u5bf9\u4e01\u578b\u809d\u708e\u6297\u539f\u7684\u6297\u4f53\uff08\u6297 HDV \u6297\u4f53\uff09\u3002\u6297 HDV \u603b\u6297\u4f53\u9633\u6027\u63d0\u793a\u66fe\u66b4\u9732\u4e8e HDV\uff08\u800c\u975e\u611f\u67d3\uff09\u3002\u4e3a\u786e\u8bca\u611f\u67d3\uff0c\u60a3\u8005\u9700\u8981\u8fdb\u884c PCR \u68c0\u6d4b\uff0c\u53ea\u6709 PCR \u68c0\u6d4b\u7ed3\u679c\u5448\u9633\u6027\u624d\u80fd\u8bca\u65ad\u4e3a HDV \u6301\u7eed\u611f\u67d3\u3002\u6240\u6709 HBsAg \u9633\u6027\u8005\u5747\u5e94\u8fdb\u884c\u6297\u4f53\u68c0\u6d4b\u3002\u4e0e HBV \u5355\u611f\u67d3\u76f8\u6bd4\uff0cCHD \u75c5\u60c5\u66f4\u4e25\u91cd\u4e14\u8fdb\u5c55\u66f4\u5feb\uff0c\u53d1\u751f\u809d\u786c\u5316\u3001\u809d\u7ec6\u80de\u764c (HCC)\u3001\u809d\u79fb\u690d\u548c\u6b7b\u4ea1\u7684\u98ce\u9669\u66f4\u9ad8\u3002\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1 (pegIFN-\u03b1) \u66fe\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u809d\u708e\uff0c\u4f46\u7597\u6548\u6301\u4e45\u6709\u9650\u3002\u6bcf\u5468\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04pegIFN-\u03b1\uff0c\u7597\u7a0b48\u5468\uff0c\u53ef\u5728\u7ea620-30%\u7684\u60a3\u8005\u4e2d\u6291\u5236HDV\u590d\u5236\uff0c\u505c\u836f24\u5468\u540e\u4ecd\u80fd\u7ef4\u6301\u7597\u6548\uff0c\u4f46\u526f\u4f5c\u7528\u663e\u8457\u3002\u5e03\u6d1b\u97e6\u80bd (BLV) \u4e8e2020\u5e74\u83b7\u5f97\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40 (EMA) \u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u809d\u708e\u548c\u4ee3\u507f\u6027\u809d\u75c5\u3002\u81ea\u83b7\u6279\u4ee5\u6765\uff0cBLV\u7684\u771f\u5b9e\u4e16\u754c\u6570\u636e\u4e0d\u65ad\u79ef\u7d2f\uff0c\u6b27\u6d32\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u5927\u591a\u60a3\u6709\u665a\u671f\u809d\u7ea4\u7ef4\u5316\u6216\u809d\u786c\u5316\u3002\u771f\u5b9e\u4e16\u754c\u6570\u636e\u8868\u660e\uff0cBLV\u7684\u7597\u6548\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u4e00\u81f4\uff0c\u8bb8\u591a\u60a3\u8005\u5728\u6cbb\u7597\u6570\u6708\u540eHDV RNA\u6c34\u5e73\u663e\u8457\u964d\u4f4e\uff0cALT\u6062\u590d\u6b63\u5e38\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002\u7136\u800c\uff0cHBsAg\u6e05\u9664\u7387\u76f8\u5bf9\u8f83\u4f4e\u3002 BLV\u8054\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\u7684\u6709\u9650\u7597\u7a0b\u53ef\u5e26\u6765\u663e\u8457\u4e14\u6301\u4e45\u7684\u7597\u6548\uff0c\u8d85\u8fc730%\u7684\u60a3\u8005\u5728\u505c\u836f\u540e\u8fbe\u5230HDV RNA\u68c0\u6d4b\u4e0d\u5230\u7684\u6c34\u5e73\u3002\u6211\u4eec\u9700\u8981\u65b0\u7684\u6709\u9650\u7597\u7a0b\u3002\u9488\u5bf9\u8fd9\u79cd\u4e25\u91cd\u7684\u75be\u75c5\uff0c\u9700\u8981\u66f4\u591a\u771f\u5b9e\u4e16\u754c\u6570\u636e\u548c\u66f4\u65b0\u7684\u7597\u6cd5\u3002.<\/p>\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link has-text-color wp-element-button\" href=\"https:\/\/cdafound.org\/wp-content\/uploads\/2026\/05\/Asselah-2025-Bulevirtide-for-chronic-hepatitis-delta.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u9605\u8bfb\u5b8c\u6574\u62a5\u544a<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Summary Hepatitis D virus (HDV) is a small RNA virus that requires Hepatitis B Surface Antigen (HBsAg) for its envelope. Eight genotypes with more than 80 % sequence homology and many subgenotypes have been described. Worldwide prevalence of chronic hepatitis delta (CHD) is estimated at about 5 % of chronic hepatitis B cases, translating to [&hellip;]<\/p>\n","protected":false},"author":939,"featured_media":9177,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[2748,2747,21,58],"publication-author":[2750,97,2751,2749],"class_list":["post-9163","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-drug-development","tag-ema","tag-hbv","tag-hdv","publication-author-helene-fontaine","publication-author-homie-razavi","publication-author-kosh-agarwal","publication-author-tarik-asselah"],"acf":[],"_links":{"self":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts\/9163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/users\/939"}],"replies":[{"embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/comments?post=9163"}],"version-history":[{"count":1,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts\/9163\/revisions"}],"predecessor-version":[{"id":9165,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts\/9163\/revisions\/9165"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/media\/9177"}],"wp:attachment":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/media?parent=9163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/categories?post=9163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/tags?post=9163"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/publication-author?post=9163"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}