{"id":9133,"date":"2025-11-19T03:17:00","date_gmt":"2025-11-19T03:17:00","guid":{"rendered":"https:\/\/cdafound.org\/?p=9133"},"modified":"2026-05-29T03:43:42","modified_gmt":"2026-05-29T03:43:42","slug":"modelling-micro-elimination-third-trimester-tenofovir-prophylaxis-for-perinatal-transmission-of-hepatitis-b-in-the-remote-dolpa-district-of-nepal","status":"publish","type":"post","link":"https:\/\/cdafound.org\/zh\/modelling-micro-elimination-third-trimester-tenofovir-prophylaxis-for-perinatal-transmission-of-hepatitis-b-in-the-remote-dolpa-district-of-nepal\/","title":{"rendered":"\u5fae\u6d88\u9664\u6a21\u578b\uff1a\u5c3c\u6cca\u5c14\u504f\u8fdc\u591a\u5c14\u5e15\u5730\u533a\u5b55\u665a\u671f\u66ff\u8bfa\u798f\u97e6\u9884\u9632\u4e59\u578b\u809d\u708e\u6bcd\u5a74\u4f20\u64ad"},"content":{"rendered":"<p>\u5728\u5c3c\u6cca\u5c14\u591a\u5c14\u5e15\u5730\u533a\uff0c\u5b55\u5987\u4e59\u578b\u809d\u708e\uff08HBV\uff09\u611f\u67d3\u7387\u6781\u9ad8\u3002\u8be5\u5730\u533a\u5730\u5904\u504f\u8fdc\uff0c\u75ab\u82d7\u63a5\u79cd\u8986\u76d6\u7387\u4f4e\u3002\u6211\u4eec\u5229\u7528\u6570\u5b66\u6a21\u578b\u8bc4\u4f30\u4e86\u598a\u5a20\u665a\u671f\u4f7f\u7528\u5bcc\u9a6c\u9178\u66ff\u8bfa\u798f\u97e6\u4e8c\u5421\u544b\u916f\uff08TDF\uff09\u9884\u9632HBV\u611f\u67d3\u5bf9HBV\u8d1f\u62c5\u7684\u5f71\u54cd\uff0c\u5e76\u4f30\u7b97\u4e86\u591a\u5c14\u5e15\u5730\u533a\u6d88\u9664HBV\u6240\u9700\u7684\u65f6\u95f4\u3002\u6211\u4eec\u5efa\u7acb\u4e86\u4e00\u4e2a\u6570\u5b66\u6a21\u578b\uff0c\u5728\u56db\u79cd\u60c5\u666f\u4e0b\u8bc4\u4f30TDF\u9884\u9632\u5bf9\u6d88\u9664HBV\u7684\u5f71\u54cd\uff1a\u57fa\u7ebf50%\u75ab\u82d7\u63a5\u79cd\u8986\u76d6\u7387\uff08\u60c5\u666fI\uff09\u300150% TDF\u8054\u5408\u57fa\u7ebf\u75ab\u82d7\u63a5\u79cd\u8986\u76d6\u7387\uff08\u60c5\u666fII\uff09\u300190% TDF\u8054\u5408\u57fa\u7ebf\u75ab\u82d7\u63a5\u79cd\u8986\u76d6\u7387\uff08\u60c5\u666fIII\uff09\u4ee5\u53ca90% TDF\u8054\u5408\u51fa\u751f\u5242\u91cf\u75ab\u82d7\u63a5\u79cd\u8986\u76d6\u7387\u548c95%\u75ab\u82d7\u63a5\u79cd\u8986\u76d6\u7387\uff08\u60c5\u666fIV\uff09\u3002\u6211\u4eec\u4f30\u7b97\u4e86TDF\u9884\u9632\u5bf9HBV\u76f8\u5173\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u7684\u5f71\u54cd\uff0c\u5e76\u9884\u6d4b\u4e86\u8be5\u5730\u533a\u6d88\u9664HBV\u6240\u9700\u7684\u65f6\u95f4\u3002\u6211\u4eec\u7684\u6a21\u578b\u8868\u660e\uff0c\u5728\u57fa\u7ebf\u5e72\u9884\u63aa\u65bd\u4e0b\uff0c\u52302100\u5e74\u591a\u5c14\u5e15\u5730\u533a\u4e0d\u592a\u53ef\u80fd\u6d88\u9664\u4e59\u809d\u75c5\u6bd2\uff08HBV\uff09\u3002\u5c06\u66ff\u8bfa\u798f\u97e6\uff08TDF\uff09\u8986\u76d6\u7387\u6269\u5927\u523090%\uff0c\u5e76\u7ed3\u5408\u57fa\u7ebf\u75ab\u82d7\u63a5\u79cd\uff0c\u53ef\u663e\u8457\u964d\u4f4eHBV\u6d41\u884c\u7387\u548cHBV\u76f8\u5173\u6b7b\u4ea1\u7387\uff0c\u4ece\u800c\u4f7f\u572860\u5e74\u5185\u6d88\u9664HBV\u6210\u4e3a\u53ef\u80fd\u3002\u5728\u51fa\u751f\u5242\u91cf\u75ab\u82d7\u63a5\u79cd\u548c95%\u5a74\u513fHBV\u75ab\u82d7\u63a5\u79cd\u8986\u76d6\u7387\u7684\u57fa\u7840\u4e0a\uff0c\u5b9e\u65bd90% TDF\uff0c\u53ef\u4ee5\u52a0\u901fHBV\u6d88\u9664\u8fdb\u7a0b\u2014\u2014\u4f7f5\u5c81\u4ee5\u4e0b\u513f\u7ae5\u7684HBV\u6d41\u884c\u7387\u22640.1%\u2014\u2014\u5e76\u57282045\u5e74\u5b9e\u73b0\u8fd9\u4e00\u76ee\u6807\u3002\u5728\u5730\u7406\u4f4d\u7f6e\u504f\u8fdc\u7684\u5730\u533a\uff0c\u91c7\u7528\u598a\u5a20\u665a\u671fTDF\u7684\u5fae\u6d88\u9664\u7b56\u7565\u662f\u63a7\u5236HBV\u7684\u4e00\u79cd\u6709\u6548\u4e14\u516c\u5e73\u7684\u7b56\u7565\u3002\u5373\u4f7f\u5728\u5b9e\u73b0\u6d88\u9664\u4e4b\u524d\uff0c\u8fd9\u79cd\u65b9\u6cd5\u4e5f\u53ef\u80fd\u5927\u5e45\u964d\u4f4eHBV\u8d1f\u62c5\u548cHBV\u76f8\u5173\u6b7b\u4ea1\u7387\uff0c\u540c\u65f6\u8fd8\u80fd\u5e94\u5bf9\u514d\u75ab\u9884\u9632\u65b9\u9762\u7684\u4e00\u4e9b\u6311\u6218\u3002.<\/p>\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link has-text-color wp-element-button\" href=\"https:\/\/cdafound.org\/wp-content\/uploads\/2026\/05\/Taye-2025-Modelling-Micro-Elimination-Third-Trimester-Tenofovir-Prophylaxis-for-Perinatal.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u9605\u8bfb\u5b8c\u6574\u62a5\u544a<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Hepatitis B (HBV) prevalence is very high in pregnant women in the Dolpa district of Nepal, a region characterised by a remote geographic landscape and low vaccination coverage. Using mathematical modelling, we evaluated the impact of third-trimester tenofovir disoproxil fumarate (TDF) prophylaxis on HBV burden and estimated the time required to achieve HBV elimination in [&hellip;]<\/p>\n","protected":false},"author":939,"featured_media":3193,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[31,21,12,2686,2687],"publication-author":[2681,80,97,92,2682,2685,2683,2684],"class_list":["post-9133","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-elimination","tag-hbv","tag-modelling","tag-mother-to-child-transmission","tag-tenofovir-prophylaxis","publication-author-belaynew-taye","publication-author-devin-razavi-shearer","publication-author-homie-razavi","publication-author-ivane-gamkrelidze","publication-author-patricia-valery","publication-author-paul-clark","publication-author-shrestha-ananta","publication-author-sudhamshu-kc"],"acf":[],"_links":{"self":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts\/9133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/users\/939"}],"replies":[{"embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/comments?post=9133"}],"version-history":[{"count":2,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts\/9133\/revisions"}],"predecessor-version":[{"id":9138,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts\/9133\/revisions\/9138"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/media\/3193"}],"wp:attachment":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/media?parent=9133"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/categories?post=9133"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/tags?post=9133"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/publication-author?post=9133"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}