{"id":2628,"date":"2015-08-24T20:05:00","date_gmt":"2015-08-24T20:05:00","guid":{"rendered":"https:\/\/cdafound.org\/?p=2628"},"modified":"2025-01-16T15:31:05","modified_gmt":"2025-01-16T15:31:05","slug":"interferon-based-hepatitis-c-antiviral-treatment-outcomes-may-be-predicted-by-alanine-aminotransferase-levels","status":"publish","type":"post","link":"https:\/\/cdafound.org\/zh\/interferon-based-hepatitis-c-antiviral-treatment-outcomes-may-be-predicted-by-alanine-aminotransferase-levels\/","title":{"rendered":"\u5e72\u6270\u7d20\u4e3a\u57fa\u7840\u7684\u4e19\u578b\u809d\u708e\u6297\u75c5\u6bd2\u6cbb\u7597\u7ed3\u679c\u53ef\u901a\u8fc7\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\u6c34\u5e73\u9884\u6d4b"},"content":{"rendered":"<h2 class=\"wp-block-heading\">\u6982\u62ec<\/h2>\n\n\n\n<p>\u5728\u5f00\u59cb\u4ee5\u5e72\u6270\u7d20\u4e3a\u57fa\u7840\u7684\u4e19\u578b\u809d\u708e\u75c5\u6bd2 (HCV) \u6297\u75c5\u6bd2\u6cbb\u7597\u540e\uff0c\u7ecf\u5e38\u4f1a\u89c2\u5bdf\u5230\u809d\u9176\u6c34\u5e73\u7684\u6cbb\u7597\u4e0b\u964d\u6216\u6b63\u5e38\u5316\uff0c\u8fd9\u53ef\u80fd\u53cd\u6620\u4e86\u5bf9\u6cbb\u7597\u7684\u53cd\u5e94\u548c HCV RNA \u6c34\u5e73\u7684\u964d\u4f4e\uff08<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4699597\/#b1-cjgh-29-407\">1<\/a>,<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4699597\/#b2-cjgh-29-407\">2<\/a>\u6cbb\u7597\u671f\u95f4\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176 (ALT) \u6c34\u5e73\u5347\u9ad8\u53ef\u80fd\u4e0e\u6301\u7eed\u6027\u75c5\u6bd2\u8840\u75c7\u6709\u5173\uff08<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4699597\/#b3-cjgh-29-407\">3<\/a>\u2013<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4699597\/#b5-cjgh-29-407\">5<\/a>).\u9176\u4fc3\u53cd\u5e94\u5728\u9884\u6d4b\u6301\u7eed\u75c5\u6bd2\u5b66\u5e94\u7b54\uff08SVR\uff09\u548c\u590d\u53d1\u65b9\u9762\u7684\u4ef7\u503c\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n\n\n\n<p>\u6211\u4eec\u8bc4\u4f30\u4e86\u57fa\u7ebf\u548c\u7b2c4\u5468ALT\u548c\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176(AST)\u6c34\u5e73\u5728\u9884\u6d4bHCV\u5bf9\u5e72\u6270\u7d20\u7c7b\u6297\u75c5\u6bd2\u6cbb\u7597\u5e94\u7b54\u4e2d\u7684\u4f5c\u7528\u3002\u672c\u7814\u7a76\u5bf92000\u5e741\u67081\u65e5\u81f32009\u5e7412\u670831\u65e5\u671f\u95f4\u5728\u6e25\u592a\u534e\u533b\u9662\u75c5\u6bd2\u6027\u809d\u708e\u95e8\u8bca\uff08\u5b89\u5927\u7565\u7701\u6e25\u592a\u534e\uff09\u63a5\u53d7HCV\u521d\u59cb\u6cbb\u7597\u7684434\u540d\u6210\u4eba\u60a3\u8005\u8fdb\u884c\u4e86\u56de\u987e\u6027\u6570\u636e\u5e93\u5206\u6790\uff08\u7814\u7a76\u4f26\u7406\u59d4\u5458\u4f1a\u7f16\u53f7\uff1a2004-196\uff09\u3002<\/p>\n\n\n\n<p><strong>\u56fd\u5bb6\uff1a<\/strong> \u52a0\u62ff\u5927<\/p>\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link has-text-color wp-element-button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4699597\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u9605\u8bfb\u5b8c\u6574\u62a5\u544a<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Summary On-therapy decline or normalization of liver enzyme levels is often observed following initiation of interferon-based hepatitis C virus (HCV) antiviral treatment and may reflect response to therapy and decreasing HCV RNA levels (1,2). On-treatment alanine aminotransferase (ALT) level elevation may be associated with persistent viremia (3\u20135). The value of enzymatic response in predicting sustained [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":3295,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[10],"publication-author":[488,1386,2087,494],"class_list":["post-2628","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-hcv","publication-author-blach-s","publication-author-cooper-c","publication-author-kelly-e","publication-author-razavi-h"],"acf":[],"_links":{"self":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts\/2628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/comments?post=2628"}],"version-history":[{"count":7,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts\/2628\/revisions"}],"predecessor-version":[{"id":7601,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts\/2628\/revisions\/7601"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/media\/3295"}],"wp:attachment":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/media?parent=2628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/categories?post=2628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/tags?post=2628"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/publication-author?post=2628"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}