{"id":2558,"date":"2017-12-01T16:25:00","date_gmt":"2017-12-01T16:25:00","guid":{"rendered":"https:\/\/cdafound.org\/?p=2558"},"modified":"2025-01-15T03:18:03","modified_gmt":"2025-01-15T03:18:03","slug":"modeling-the-epidemic-of-nonalcoholic-fatty-liver-disease-demonstrates-an-exponential-increase-in-burden-of-disease","status":"publish","type":"post","link":"https:\/\/cdafound.org\/zh\/modeling-the-epidemic-of-nonalcoholic-fatty-liver-disease-demonstrates-an-exponential-increase-in-burden-of-disease\/","title":{"rendered":"\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u75be\u75c5\u6d41\u884c\u7684\u6a21\u578b\u8868\u660e\u75be\u75c5\u8d1f\u62c5\u5448\u6307\u6570\u7ea7\u589e\u957f"},"content":{"rendered":"<h2 class=\"wp-block-heading\">\u6982\u62ec<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u75c5 (NAFLD) \u53ca\u5176\u5f15\u53d1\u7684\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e (NASH) \u5728\u7f8e\u56fd\u975e\u5e38\u666e\u904d\uff0c\u5b83\u4eec\u5df2\u6210\u4e3a\u809d\u786c\u5316\u548c\u809d\u7ec6\u80de\u764c (HCC) \u65e5\u76ca\u589e\u957f\u7684\u75c5\u56e0\uff0c\u5e76\u65e5\u76ca\u6210\u4e3a\u809d\u79fb\u690d\u7684\u6307\u6807\u3002\u672c\u7814\u7a76\u4f7f\u7528\u9a6c\u5c14\u53ef\u592b\u6a21\u578b\u9884\u6d4b NAFLD \u7684\u75c5\u60c5\u8fdb\u5c55\u3002NAFLD \u7684\u53d1\u75c5\u7387\u57fa\u4e8e\u6210\u4eba\u80a5\u80d6\u548c 2 \u578b\u7cd6\u5c3f\u75c5 (DM) \u60a3\u75c5\u7387\u7684\u5386\u53f2\u548c\u9884\u6d4b\u53d8\u5316\u3002\u6240\u6709\u5047\u8bbe\u5747\u6765\u81ea\u5df2\u53d1\u8868\u7684\u6587\u732e\uff08\u5982\u6709\uff09\uff0c\u5e76\u4f7f\u7528 NAFLD \u76f8\u5173 HCC \u53d1\u75c5\u7387\u7684\u56fd\u5bb6\u76d1\u6d4b\u6570\u636e\u8fdb\u884c\u9a8c\u8bc1\u3002\u9884\u6d4b\u4e86\u52302030\u5e74NAFLD\u76f8\u5173\u809d\u786c\u5316\u3001\u665a\u671f\u809d\u75c5\u548c\u809d\u810f\u76f8\u5173\u6b7b\u4ea1\u7387\u7684\u53d8\u5316\u3002\u9884\u6d4bNAFLD\u60a3\u75c5\u4eba\u6570\u5c06\u589e\u52a021%\uff0c\u4ece2015\u5e74\u76848310\u4e07\u589e\u52a0\u52302030\u5e74\u76841.009\u4ebf\uff1bNASH\u60a3\u75c5\u4eba\u6570\u5c06\u589e\u52a063%\uff0c\u4ece1652\u4e07\u589e\u52a0\u52302700\u4e07\u3002\u9884\u8ba1\u52302030\u5e74\uff0c\u6210\u5e74\u4eba\u53e3\uff08\u226515\u5c81\uff09\u7684NAFLD\u603b\u4f53\u60a3\u75c5\u7387\u4e3a33.5%\uff0cNAFLD\u60a3\u8005\u7684\u4e2d\u4f4d\u5e74\u9f84\u5c06\u4ece2015\u5e74\u768450\u5c81\u589e\u52a0\u52302030\u5e74\u768455\u5c81\u30022015\u5e74\uff0c\u7ea6\u670920%\u7684NAFLD\u75c5\u4f8b\u88ab\u5f52\u7c7b\u4e3aNASH\uff0c\u52302030\u5e74\u5c06\u589e\u52a0\u523027%\uff0c\u8fd9\u65e2\u53cd\u6620\u4e86\u75be\u75c5\u8fdb\u5c55\uff0c\u4e5f\u53cd\u6620\u4e86\u4eba\u53e3\u8001\u9f84\u5316\u3002\u52302030\u5e74\uff0c\u5931\u4ee3\u507f\u6027\u809d\u786c\u5316\u53d1\u75c5\u7387\u5c06\u589e\u52a0168%\uff0c\u8fbe\u5230105,430\u4f8b\uff1b\u809d\u7ec6\u80de\u764c\u53d1\u75c5\u7387\u5c06\u589e\u52a0137%\uff0c\u8fbe\u523012,240\u4f8b\u3002\u52302030\u5e74\uff0c\u809d\u810f\u75be\u75c5\u6b7b\u4ea1\u4eba\u6570\u5c06\u589e\u52a0178%\uff0c\u9884\u8ba1\u6b7b\u4ea1\u4eba\u6570\u4e3a78,300\u4eba\u30022015\u5e74\u81f32030\u5e74\u671f\u95f4\uff0c\u9884\u8ba1\u65b0\u589e\u8fd180\u4e07\u4f8b\u809d\u810f\u75be\u75c5\u6b7b\u4ea1\u75c5\u4f8b\u3002 <\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u7ed3\u8bba<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u968f\u7740\u6210\u4eba\u80a5\u80d6\u548c\u7cd6\u5c3f\u75c5\u53d1\u75c5\u7387\u6301\u7eed\u5c45\u9ad8\u4e0d\u4e0b\uff0c\u4ee5\u53ca\u4eba\u53e3\u8001\u9f84\u5316\uff0c\u7f8e\u56fdNAFLD\u76f8\u5173\u7684\u809d\u75c5\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u5c06\u6301\u7eed\u4e0a\u5347\u3002\u51cf\u7f13NAFLD\u75c5\u4f8b\u589e\u957f\u7684\u7b56\u7565\u548c\u6cbb\u7597\u65b9\u6848\u5bf9\u4e8e\u51cf\u8f7b\u75be\u75c5\u8d1f\u62c5\u81f3\u5173\u91cd\u8981\u3002(Hepatology 2018;67:123-133)\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u56fd\u5bb6\uff1a<\/strong> \u7f8e\u56fd<\/p>\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link has-text-color wp-element-button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28802062\" target=\"_blank\" rel=\"noreferrer noopener\">\u9605\u8bfb\u5b8c\u6574\u62a5\u544a<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Summary Nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are highly prevalent in the United States, where they are a growing cause of cirrhosis and hepatocellular carcinoma (HCC) and increasingly an indicator for liver transplantation. A Markov model was used to forecast NAFLD disease progression. Incidence of NAFLD was based on historical and [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":3479,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[12,24],"publication-author":[535,872,494,909,908],"class_list":["post-2558","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-modelling","tag-nafld","publication-author-estes-c","publication-author-loomba-r","publication-author-razavi-h","publication-author-sanyal-aj","publication-author-younossi-z"],"acf":[],"_links":{"self":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts\/2558","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/comments?post=2558"}],"version-history":[{"count":7,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts\/2558\/revisions"}],"predecessor-version":[{"id":7545,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/posts\/2558\/revisions\/7545"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/media\/3479"}],"wp:attachment":[{"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/media?parent=2558"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/categories?post=2558"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/tags?post=2558"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/cdafound.org\/zh\/wp-json\/wp\/v2\/publication-author?post=2558"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}