{"id":9133,"date":"2025-11-19T03:17:00","date_gmt":"2025-11-19T03:17:00","guid":{"rendered":"https:\/\/cdafound.org\/?p=9133"},"modified":"2026-05-29T03:43:42","modified_gmt":"2026-05-29T03:43:42","slug":"modelling-micro-elimination-third-trimester-tenofovir-prophylaxis-for-perinatal-transmission-of-hepatitis-b-in-the-remote-dolpa-district-of-nepal","status":"publish","type":"post","link":"https:\/\/cdafound.org\/ru\/modelling-micro-elimination-third-trimester-tenofovir-prophylaxis-for-perinatal-transmission-of-hepatitis-b-in-the-remote-dolpa-district-of-nepal\/","title":{"rendered":"\u041c\u043e\u0434\u0435\u043b\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u043c\u0438\u043a\u0440\u043e\u044d\u043b\u0438\u043c\u0438\u043d\u0430\u0446\u0438\u0438: \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0430 \u043f\u0435\u0440\u0438\u043d\u0430\u0442\u0430\u043b\u044c\u043d\u043e\u0439 \u043f\u0435\u0440\u0435\u0434\u0430\u0447\u0438 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412 \u0441 \u043f\u043e\u043c\u043e\u0449\u044c\u044e \u0442\u0435\u043d\u043e\u0444\u043e\u0432\u0438\u0440\u0430 \u0432 \u0442\u0440\u0435\u0442\u044c\u0435\u043c \u0442\u0440\u0438\u043c\u0435\u0441\u0442\u0440\u0435 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u0432 \u043e\u0442\u0434\u0430\u043b\u0435\u043d\u043d\u043e\u043c \u0440\u0430\u0439\u043e\u043d\u0435 \u0414\u043e\u043b\u043f\u0430 \u0432 \u041d\u0435\u043f\u0430\u043b\u0435."},"content":{"rendered":"

\u0420\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0412 (HBV) \u0441\u0440\u0435\u0434\u0438 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0445 \u0436\u0435\u043d\u0449\u0438\u043d \u0432 \u0440\u0430\u0439\u043e\u043d\u0435 \u0414\u043e\u043b\u043f\u0430 \u0432 \u041d\u0435\u043f\u0430\u043b\u0435 \u043e\u0447\u0435\u043d\u044c \u0432\u044b\u0441\u043e\u043a\u0430. \u042d\u0442\u043e\u0442 \u0440\u0435\u0433\u0438\u043e\u043d \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0437\u0443\u0435\u0442\u0441\u044f \u0443\u0434\u0430\u043b\u0435\u043d\u043d\u044b\u043c \u0433\u0435\u043e\u0433\u0440\u0430\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u043b\u0430\u043d\u0434\u0448\u0430\u0444\u0442\u043e\u043c \u0438 \u043d\u0438\u0437\u043a\u0438\u043c \u0443\u0440\u043e\u0432\u043d\u0435\u043c \u0432\u0430\u043a\u0446\u0438\u043d\u0430\u0446\u0438\u0438. \u0418\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u044f \u043c\u0430\u0442\u0435\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u043c\u043e\u0434\u0435\u043b\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435, \u043c\u044b \u043e\u0446\u0435\u043d\u0438\u043b\u0438 \u0432\u043b\u0438\u044f\u043d\u0438\u0435 \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0438 \u0442\u0435\u043d\u043e\u0444\u043e\u0432\u0438\u0440\u043e\u043c \u0434\u0438\u0437\u043e\u043f\u0440\u043e\u043a\u0441\u0438\u043b\u0444\u0443\u043c\u0430\u0440\u0430\u0442\u043e\u043c (TDF) \u0432 \u0442\u0440\u0435\u0442\u044c\u0435\u043c \u0442\u0440\u0438\u043c\u0435\u0441\u0442\u0440\u0435 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u043d\u0430 \u0431\u0440\u0435\u043c\u044f HBV \u0438 \u043e\u0446\u0435\u043d\u0438\u043b\u0438 \u0432\u0440\u0435\u043c\u044f, \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e\u0435 \u0434\u043b\u044f \u0434\u043e\u0441\u0442\u0438\u0436\u0435\u043d\u0438\u044f \u044d\u043b\u0438\u043c\u0438\u043d\u0430\u0446\u0438\u0438 HBV \u0432 \u0414\u043e\u043b\u043f\u0435. \u041c\u044b \u0440\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u0430\u043b\u0438 \u043c\u0430\u0442\u0435\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0443\u044e \u043c\u043e\u0434\u0435\u043b\u044c \u0434\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 \u0432\u043b\u0438\u044f\u043d\u0438\u044f \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0438 TDF \u043d\u0430 \u044d\u043b\u0438\u043c\u0438\u043d\u0430\u0446\u0438\u044e HBV \u0432 \u0447\u0435\u0442\u044b\u0440\u0435\u0445 \u0441\u0446\u0435\u043d\u0430\u0440\u0438\u044f\u0445: \u0431\u0430\u0437\u043e\u0432\u044b\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0432\u0430\u043a\u0446\u0438\u043d\u0430\u0446\u0438\u0438 50% (\u0441\u0446\u0435\u043d\u0430\u0440\u0438\u0439 I), 50% TDF \u0438 \u0431\u0430\u0437\u043e\u0432\u044b\u0439 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0432\u0430\u043a\u0446\u0438\u043d\u0430\u0446\u0438\u0438 (\u0441\u0446\u0435\u043d\u0430\u0440\u0438\u0439 II), 90% TDF \u043f\u043b\u044e\u0441 \u0431\u0430\u0437\u043e\u0432\u0430\u044f \u0432\u0430\u043a\u0446\u0438\u043d\u0430\u0446\u0438\u044f (\u0441\u0446\u0435\u043d\u0430\u0440\u0438\u0439 III) \u0438 90% TDF \u0438 \u0432\u0430\u043a\u0446\u0438\u043d\u0430\u0446\u0438\u044f \u043f\u0440\u0438 \u0440\u043e\u0436\u0434\u0435\u043d\u0438\u0438 \u043f\u043b\u044e\u0441 95% (\u0441\u0446\u0435\u043d\u0430\u0440\u0438\u0439 IV). \u041c\u044b \u043e\u0446\u0435\u043d\u0438\u043b\u0438 \u0432\u043b\u0438\u044f\u043d\u0438\u0435 \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0438 TDF \u043d\u0430 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u0435\u043c\u043e\u0441\u0442\u044c \u0438 \u0441\u043c\u0435\u0440\u0442\u043d\u043e\u0441\u0442\u044c, \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u044b\u0435 \u0441 HBV, \u0438 \u0441\u043f\u0440\u043e\u0433\u043d\u043e\u0437\u0438\u0440\u043e\u0432\u0430\u043b\u0438 \u0432\u0440\u0435\u043c\u044f, \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e\u0435 \u0434\u043b\u044f \u044d\u043b\u0438\u043c\u0438\u043d\u0430\u0446\u0438\u0438 HBV \u0432 \u0440\u0430\u0439\u043e\u043d\u0435. \u041d\u0430\u0448\u0430 \u043c\u043e\u0434\u0435\u043b\u044c \u043f\u0440\u0435\u0434\u043f\u043e\u043b\u0430\u0433\u0430\u0435\u0442, \u0447\u0442\u043e \u044d\u043b\u0438\u043c\u0438\u043d\u0430\u0446\u0438\u044f \u0412\u0413\u0412 \u0432 \u0414\u043e\u043b\u043f\u0435 \u043a 2100 \u0433\u043e\u0434\u0443 \u043f\u0440\u0438 \u0431\u0430\u0437\u043e\u0432\u044b\u0445 \u043c\u0435\u0440\u0430\u0445 \u0432\u043c\u0435\u0448\u0430\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0430 \u043c\u0430\u043b\u043e\u0432\u0435\u0440\u043e\u044f\u0442\u043d\u0430. \u0420\u0430\u0441\u0448\u0438\u0440\u0435\u043d\u0438\u0435 \u043e\u0445\u0432\u0430\u0442\u0430 \u0432\u0430\u043a\u0446\u0438\u043d\u0430\u0446\u0438\u0435\u0439 \u0442\u0435\u043d\u043e\u0444\u043e\u0432\u0438\u0440\u043e\u043c (TDF) \u0434\u043e 90% \u0432 \u0440\u0430\u043c\u043a\u0430\u0445 \u0431\u0430\u0437\u043e\u0432\u043e\u0439 \u0432\u0430\u043a\u0446\u0438\u043d\u0430\u0446\u0438\u0438 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u0441\u043d\u0438\u0436\u0430\u0435\u0442 \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u0412\u0413\u0412 \u0438 \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u0443\u044e \u0441 \u043d\u0438\u043c \u0441\u043c\u0435\u0440\u0442\u043d\u043e\u0441\u0442\u044c, \u0447\u0442\u043e \u0434\u0435\u043b\u0430\u0435\u0442 \u044d\u043b\u0438\u043c\u0438\u043d\u0430\u0446\u0438\u044e \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0439 \u0432 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435 \u0434\u043e 60 \u043b\u0435\u0442. \u0412\u043d\u0435\u0434\u0440\u0435\u043d\u0438\u0435 90% TDF \u043d\u0430\u0440\u044f\u0434\u0443 \u0441 \u0432\u0430\u043a\u0446\u0438\u043d\u0430\u0446\u0438\u0435\u0439 \u043d\u043e\u0432\u043e\u0440\u043e\u0436\u0434\u0435\u043d\u043d\u044b\u0445 \u0438 \u043e\u0445\u0432\u0430\u0442\u043e\u043c \u0432\u0430\u043a\u0446\u0438\u043d\u0430\u0446\u0438\u0435\u0439 \u043c\u043b\u0430\u0434\u0435\u043d\u0446\u0435\u0432 \u043f\u0440\u043e\u0442\u0438\u0432 \u0412\u0413\u0412 95% \u043c\u043e\u0436\u0435\u0442 \u0443\u0441\u043a\u043e\u0440\u0438\u0442\u044c \u044d\u043b\u0438\u043c\u0438\u043d\u0430\u0446\u0438\u044e \u0412\u0413\u0412 \u2014 \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u0412\u0413\u0412 \u0441\u0440\u0435\u0434\u0438 \u0434\u0435\u0442\u0435\u0439 \u043c\u043b\u0430\u0434\u0448\u0435 5 \u043b\u0435\u0442 \u22640,1% \u2014 \u0434\u043e\u0441\u0442\u0438\u0433\u043d\u0443\u0432 \u0435\u0435 \u043a 2045 \u0433\u043e\u0434\u0443. \u0412 \u0433\u0435\u043e\u0433\u0440\u0430\u0444\u0438\u0447\u0435\u0441\u043a\u0438 \u0442\u0440\u0443\u0434\u043d\u043e\u0434\u043e\u0441\u0442\u0443\u043f\u043d\u044b\u0445 \u0440\u0435\u0433\u0438\u043e\u043d\u0430\u0445 \u043c\u0438\u043a\u0440\u043e\u044d\u043b\u0438\u043c\u0438\u043d\u0430\u0446\u0438\u043e\u043d\u043d\u044b\u0439 \u043f\u043e\u0434\u0445\u043e\u0434 \u0441 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435\u043c TDF \u0432 \u0442\u0440\u0435\u0442\u044c\u0435\u043c \u0442\u0440\u0438\u043c\u0435\u0441\u0442\u0440\u0435 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0439 \u0438 \u0441\u043f\u0440\u0430\u0432\u0435\u0434\u043b\u0438\u0432\u043e\u0439 \u0441\u0442\u0440\u0430\u0442\u0435\u0433\u0438\u0435\u0439 \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u044f \u0412\u0413\u0412. \u042d\u0442\u043e\u0442 \u043f\u043e\u0434\u0445\u043e\u0434, \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e, \u0441\u0443\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e \u0441\u043d\u0438\u0437\u0438\u0442 \u0431\u0440\u0435\u043c\u044f \u0412\u0413\u0412 \u0438 \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u0443\u044e \u0441 \u043d\u0438\u043c \u0441\u043c\u0435\u0440\u0442\u043d\u043e\u0441\u0442\u044c \u0434\u0430\u0436\u0435 \u0434\u043e \u0434\u043e\u0441\u0442\u0438\u0436\u0435\u043d\u0438\u044f \u044d\u043b\u0438\u043c\u0438\u043d\u0430\u0446\u0438\u0438, \u0430 \u0442\u0430\u043a\u0436\u0435 \u0440\u0435\u0448\u0438\u0442 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u043f\u0440\u043e\u0431\u043b\u0435\u043c\u044b \u0438\u043c\u043c\u0443\u043d\u043e\u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0438.<\/p>\n\n

\n
\u0427\u0438\u0442\u0430\u0442\u044c \u043f\u043e\u043b\u043d\u044b\u0439 \u043e\u0442\u0447\u0435\u0442<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Hepatitis B (HBV) prevalence is very high in pregnant women in the Dolpa district of Nepal, a region characterised by a remote geographic landscape and low vaccination coverage. Using mathematical modelling, we evaluated the impact of third-trimester tenofovir disoproxil fumarate (TDF) prophylaxis on HBV burden and estimated the time required to achieve HBV elimination in […]<\/p>\n","protected":false},"author":939,"featured_media":3193,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[31,21,12,2686,2687],"publication-author":[2681,80,97,92,2682,2685,2683,2684],"class_list":["post-9133","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-elimination","tag-hbv","tag-modelling","tag-mother-to-child-transmission","tag-tenofovir-prophylaxis","publication-author-belaynew-taye","publication-author-devin-razavi-shearer","publication-author-homie-razavi","publication-author-ivane-gamkrelidze","publication-author-patricia-valery","publication-author-paul-clark","publication-author-shrestha-ananta","publication-author-sudhamshu-kc"],"acf":[],"_links":{"self":[{"href":"https:\/\/cdafound.org\/ru\/wp-json\/wp\/v2\/posts\/9133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdafound.org\/ru\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdafound.org\/ru\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdafound.org\/ru\/wp-json\/wp\/v2\/users\/939"}],"replies":[{"embeddable":true,"href":"https:\/\/cdafound.org\/ru\/wp-json\/wp\/v2\/comments?post=9133"}],"version-history":[{"count":2,"href":"https:\/\/cdafound.org\/ru\/wp-json\/wp\/v2\/posts\/9133\/revisions"}],"predecessor-version":[{"id":9138,"href":"https:\/\/cdafound.org\/ru\/wp-json\/wp\/v2\/posts\/9133\/revisions\/9138"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdafound.org\/ru\/wp-json\/wp\/v2\/media\/3193"}],"wp:attachment":[{"href":"https:\/\/cdafound.org\/ru\/wp-json\/wp\/v2\/media?parent=9133"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdafound.org\/ru\/wp-json\/wp\/v2\/categories?post=9133"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdafound.org\/ru\/wp-json\/wp\/v2\/tags?post=9133"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/cdafound.org\/ru\/wp-json\/wp\/v2\/publication-author?post=9133"}],"curies":[{"name":"WP","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}