{"id":4336,"date":"2018-08-10T18:47:00","date_gmt":"2018-08-10T18:47:00","guid":{"rendered":"https:\/\/cdafound.org\/?p=4336"},"modified":"2025-01-15T03:09:39","modified_gmt":"2025-01-15T03:09:39","slug":"forecasting-hepatitis-c-liver-disease-burden-on-real-life-data-does-the-hidden-iceberg-matter-to-reach-the-elimination-goals","status":"publish","type":"post","link":"https:\/\/cdafound.org\/fr\/forecasting-hepatitis-c-liver-disease-burden-on-real-life-data-does-the-hidden-iceberg-matter-to-reach-the-elimination-goals\/","title":{"rendered":"Pr\u00e9vision du fardeau de l'h\u00e9patite C sur des donn\u00e9es r\u00e9elles. L'iceberg cach\u00e9 est-il important pour atteindre les objectifs d'\u00e9limination ?"},"content":{"rendered":"

R\u00e9sum\u00e9<\/h2>\n\n\n\n

Contexte et objectifs<\/h3>\n\n\n\n

Les progr\u00e8s dans le traitement antiviral \u00e0 action directe du VHC ont redynamis\u00e9 les initiatives de sant\u00e9 publique visant \u00e0 identifier les personnes affect\u00e9es. Nous avons \u00e9valu\u00e9 l'impact possible des seules personnes diagnostiqu\u00e9es et li\u00e9es aux soins sur les estimations globales du fardeau du VHC et identifi\u00e9 une strat\u00e9gie possible pour atteindre les cibles de l'OMS d'ici 2030.<\/p>\n\n\n\n

M\u00e9thodes<\/h3>\n\n\n\n

\u00c0 l'aide d'une approche de mod\u00e9lisation fond\u00e9e sur des donn\u00e9es italiennes r\u00e9elles de patients diagnostiqu\u00e9s et trait\u00e9s, diff\u00e9rents sc\u00e9narios de lien avec les soins ont \u00e9t\u00e9 \u00e9labor\u00e9s pour \u00e9valuer les strat\u00e9gies potentielles pour atteindre les objectifs d'\u00e9limination du VHC.<\/p>\n\n\n\n

R\u00e9sultats<\/h3>\n\n\n\n

Dans le sc\u00e9nario 40% li\u00e9 aux soins, la charge vir\u00e9mique diminuerait (60%) ; cependant, les patients \u00e9ligibles \u00e0 traiter seront \u00e9puis\u00e9s d'ici 2025. Une recherche accrue de cas gr\u00e2ce \u00e0 une strat\u00e9gie de d\u00e9pistage cibl\u00e9 dans les cohortes de naissance de 1948-1978 pourrait compl\u00e9ter le groupe de patients diagnostiqu\u00e9s en trouvant 751 TP1T des cas F0-F3. Dans le sc\u00e9nario 60% li\u00e9 aux soins, les infections vir\u00e9miques diminueraient de 70% d'ici 2030, mais les patients \u00e9ligibles au traitement seront \u00e9puis\u00e9s d'ici 2028. Si le traitement doit \u00eatre maintenu, une strat\u00e9gie de d\u00e9pistage ax\u00e9e sur les cohortes de naissance 1958-1978 pourrait capturer 55% des individus F0-F3. Dans le sc\u00e9nario 80% li\u00e9 aux soins, le d\u00e9pistage limit\u00e9 dans les cohortes de naissance 1968-1978 pourrait maintenir le traitement aux niveaux requis pour atteindre les objectifs d'\u00e9limination du VHC.<\/p>\n\n\n\n

Conclusion <\/h3>\n\n\n\n

En Italie, qui est un pays d'end\u00e9mie du VHC, le pool de patients \u00e9ligibles \u00e0 traiter s'\u00e9puisera entre 2025 et 2028. Pour maintenir le taux de traitement et atteindre les objectifs d'\u00e9limination du VHC, une recherche accrue de cas dans les groupes cibl\u00e9s \u00e0 forte pr\u00e9valence est n\u00e9cessaire.<\/p>\n\n\n\n

Des pays:<\/strong> Italie<\/p>\n\n

\n
Lire le rapport complet<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Summary Background & Aims Advances in direct acting anti-viral treatment of HCV have reinvigorated public health initiatives aimed at identifying affected individuals. We evaluated the possible impact of only diagnosed and linked-to-care individuals on overall HCV burden estimates and identified a possible strategy to achieve the WHO targets by 2030. Methods Using a modelling approach […]<\/p>\n","protected":false},"author":24,"featured_media":3486,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[10],"publication-author":[809,827,488,816,821,826,808,820,819,815,813,680,810,811,542,823,831,803,822,668,814,830,818,829,832,824,825,725,722,828,800,494,807,812,805,799,806,802,724,817,801,804],"class_list":["post-4336","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-hcv","publication-author-andreone-p","publication-author-andriulli-a","publication-author-blach-s","publication-author-blanc-p","publication-author-borgia-g","publication-author-brancaccio-g","publication-author-brunetto-mr","publication-author-caporaso-n","publication-author-chessa-l","publication-author-ciancio-a","publication-author-coppola-c","publication-author-craxi-a-2","publication-author-erne-em","publication-author-federico-a","publication-author-gamkrelidze-i","publication-author-gasbarrini-a","publication-author-gori-a","publication-author-iannone-a","publication-author-ieluzzi-d","publication-author-kondili-la","publication-author-lampertico-p","publication-author-madonia-s","publication-author-massari-m","publication-author-melazzini-m","publication-author-montilla-s","publication-author-orlandini-a","publication-author-persico-m","publication-author-piter-collaborating-group","publication-author-puoti-m","publication-author-quaranta-mg","publication-author-raimondo-g","publication-author-razavi-h","publication-author-robbins-s","publication-author-rumi-mg","publication-author-russo-fp","publication-author-santantonio-ta","publication-author-strazzabosco-m","publication-author-taliani-g","publication-author-vella-s","publication-author-vinci-m","publication-author-zignego-al","publication-author-zuin-m"],"acf":[],"_links":{"self":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/4336","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/comments?post=4336"}],"version-history":[{"count":3,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/4336\/revisions"}],"predecessor-version":[{"id":7530,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/4336\/revisions\/7530"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/media\/3486"}],"wp:attachment":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/media?parent=4336"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/categories?post=4336"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/tags?post=4336"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/publication-author?post=4336"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}