{"id":3089,"date":"2020-06-09T16:23:00","date_gmt":"2020-06-09T16:23:00","guid":{"rendered":"https:\/\/cdafound.org\/?p=3089"},"modified":"2025-01-14T22:08:33","modified_gmt":"2025-01-14T22:08:33","slug":"burden-of-nonalcoholic-fatty-liver-disease-in-canada-2019-2030-a-modelling-study","status":"publish","type":"post","link":"https:\/\/cdafound.org\/fr\/burden-of-nonalcoholic-fatty-liver-disease-in-canada-2019-2030-a-modelling-study\/","title":{"rendered":"Fardeau de la st\u00e9atose h\u00e9patique non alcoolique au Canada, 2019-2030: une \u00e9tude de mod\u00e9lisation"},"content":{"rendered":"

R\u00e9sum\u00e9<\/h2>\n\n\n\n

Arri\u00e8re-plan<\/h3>\n\n\n\n

La st\u00e9atose h\u00e9patique non alcoolique (NAFLD) et la st\u00e9atoh\u00e9patite non alcoolique (NASH) repr\u00e9sentent une proportion croissante de cas de maladie h\u00e9patique, et il est n\u00e9cessaire de mieux comprendre la charge de morbidit\u00e9 future. Nous avons utilis\u00e9 un cadre de mod\u00e9lisation pour pr\u00e9voir le fardeau de la maladie de la NAFLD et de la NASH au Canada.<\/p>\n\n\n\n

M\u00e9thodes<\/h3>\n\n\n\n

Nous avons utilis\u00e9 un mod\u00e8le de Markov pour pr\u00e9voir la progression de la fibrose du stade F0 (pas de fibrose) au stade F4 (cirrhose compens\u00e9e) et la progression subs\u00e9quente vers la cirrhose d\u00e9compens\u00e9e, le carcinome h\u00e9patocellulaire, la transplantation h\u00e9patique et la mort li\u00e9e au foie chez les Canadiens atteints de NAFLD de 2019 \u00e0 2030. Nous a utilis\u00e9 les tendances historiques de la pr\u00e9valence de l'ob\u00e9sit\u00e9 chez les adultes pour estimer les changements longitudinaux du nombre de cas incidents de NAFLD.<\/p>\n\n\n\n

R\u00e9sultats<\/h3>\n\n\n\n

Le mod\u00e8le pr\u00e9voyait que le nombre de cas de NAFLD augmenterait de 20% entre 2019 et 2030, passant d'environ 7 757 000 cas \u00e0 9 305 000 cas. Les augmentations des cas de fibrose avanc\u00e9e \u00e9taient relativement plus importantes, car le nombre de cas pr\u00e9valents de stade F3 estim\u00e9 par le mod\u00e8le augmenterait de 65%, \u00e0 357 000, et celui des cas pr\u00e9valents de stade F4 augmenterait de 95%, \u00e0 195 000. Estimation des cas incidents d'h\u00e9patocellulaire le carcinome et la cirrhose d\u00e9compens\u00e9e augmenteraient jusqu'\u00e0 95%, et le nombre de d\u00e9c\u00e8s annuels li\u00e9s \u00e0 la NAFLD doublerait, \u00e0 5600.<\/p>\n\n\n\n

Interpr\u00e9tation<\/h3>\n\n\n\n

L'augmentation des taux d'ob\u00e9sit\u00e9 se traduit par une augmentation des cas de cirrhose et de carcinome h\u00e9patocellulaire li\u00e9s \u00e0 la NAFLD et de la mortalit\u00e9 associ\u00e9e. Les efforts de pr\u00e9vention doivent viser \u00e0 r\u00e9duire l'incidence de la NAFLD et \u00e0 ralentir la progression de la fibrose chez les personnes d\u00e9j\u00e0 touch\u00e9es.<\/p>\n\n\n\n

Des pays:<\/strong> Canada<\/p>\n\n\n\n

\n
Lire le rapport complet<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Summary Background Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) account for a growing proportion of liver disease cases, and there is a need to better understand future disease burden. We used a modelling framework to forecast the burden of disease of NAFLD and NASH for Canada. Methods We used a Markov model to […]<\/p>\n","protected":false},"author":24,"featured_media":3162,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[12,24],"publication-author":[699,698,535,697,701,695,494,700,702,696,703],"class_list":["post-3089","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-modelling","tag-nafld","publication-author-bajaj-hs","publication-author-elkhashab-m","publication-author-estes-c","publication-author-marotta-p","publication-author-patel-k","publication-author-ramji-a","publication-author-razavi-h","publication-author-sebastiani-g","publication-author-shaheen-aa","publication-author-swain-mg","publication-author-tam-e"],"acf":[],"_links":{"self":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/3089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/comments?post=3089"}],"version-history":[{"count":5,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/3089\/revisions"}],"predecessor-version":[{"id":7473,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/3089\/revisions\/7473"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/media\/3162"}],"wp:attachment":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/media?parent=3089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/categories?post=3089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/tags?post=3089"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/publication-author?post=3089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}