{"id":2596,"date":"2016-07-01T17:48:00","date_gmt":"2016-07-01T17:48:00","guid":{"rendered":"https:\/\/cdafound.org\/?p=2596"},"modified":"2025-01-15T20:27:00","modified_gmt":"2025-01-15T20:27:00","slug":"epidemiology-disease-burden-and-treatment-strategies-of-chronic-hepatitis-c-virus-infections-in-saudi-arabia-in-the-new-treatment-paradigm-shift","status":"publish","type":"post","link":"https:\/\/cdafound.org\/fr\/epidemiology-disease-burden-and-treatment-strategies-of-chronic-hepatitis-c-virus-infections-in-saudi-arabia-in-the-new-treatment-paradigm-shift\/","title":{"rendered":"\u00c9pid\u00e9miologie, charge de morbidit\u00e9 et strat\u00e9gies de traitement des infections chroniques par le virus de l'h\u00e9patite C en Arabie saoudite dans le cadre du nouveau changement de paradigme de traitement"},"content":{"rendered":"

R\u00e9sum\u00e9<\/h2>\n\n\n\n

Contexte \/ Objectifs<\/h3>\n\n\n\n

On estime qu'environ 101 000 personnes sont vir\u00e9miques du virus de l'h\u00e9patite C chronique (VHC) dans le Royaume d'Arabie saoudite (KSA) en 2014; cependant, seuls environ 20% ont \u00e9t\u00e9 diagnostiqu\u00e9s. Nous visons \u00e0 \u00e9valuer l'\u00e9pid\u00e9miologie de base, le fardeau de la maladie et \u00e0 \u00e9valuer les strat\u00e9gies pour \u00e9liminer le VHC en Arabie saoudite. <\/p>\n\n\n\n

Mat\u00e9riels et m\u00e9thodes<\/h3>\n\n\n\n

La population infect\u00e9e et la progression de la maladie ont \u00e9t\u00e9 mod\u00e9lis\u00e9es \u00e0 l'aide de cohortes d\u00e9finies par l'\u00e2ge et le sexe pour suivre l'incidence, la pr\u00e9valence, les complications h\u00e9patiques et la mortalit\u00e9 du VHC. Les hypoth\u00e8ses de base et les probabilit\u00e9s de transition ont \u00e9t\u00e9 extraites de la litt\u00e9rature. Les impacts de deux sc\u00e9narios sur la charge de morbidit\u00e9 li\u00e9e au VHC ont \u00e9t\u00e9 pris en compte par l'augmentation de l'efficacit\u00e9 du traitement seul ou du traitement et du diagnostic. <\/p>\n\n\n\n

R\u00e9sultats<\/h3>\n\n\n\n

En 2030, le sc\u00e9nario de base estime que la pr\u00e9valence vir\u00e9mique augmentera \u00e0 103 000 cas, le carcinome h\u00e9patocellulaire (CHC) \u00e0 470, les cas de cirrhose d\u00e9compens\u00e9s et compens\u00e9s \u00e0 1 300 et 15 400, respectivement, et la mortalit\u00e9 li\u00e9e au foie \u00e0 670 d\u00e9c\u00e8s. L'utilisation d'un seul traitement \u00e0 haute efficacit\u00e9 a abouti \u00e0 une projection en 2030 de 80 700 cas vir\u00e9miques, 350 cas de CHC, 480 d\u00e9c\u00e8s li\u00e9s au foie et 850 et 11500 cas de cirrhose d\u00e9compens\u00e9s et compens\u00e9s, respectivement. Avec une strat\u00e9gie de traitement agressive, en 2030, il y aura environ 1700 cas vir\u00e9miques, 1 cas de CHC, environ 20 d\u00e9c\u00e8s li\u00e9s au foie et 5 et 130 cas de cirrhose d\u00e9compens\u00e9e et compens\u00e9e, respectivement. Retarder cette strat\u00e9gie d'un an entra\u00eenerait 360 d\u00e9c\u00e8s suppl\u00e9mentaires d'ici 2030. <\/p>\n\n\n\n

Conclusions<\/h3>\n\n\n\n

Le VHC dans le KSA reste constant, et les cas de maladie h\u00e9patique avanc\u00e9e et de mortalit\u00e9 continuent d'augmenter. Des augmentations consid\u00e9r\u00e9es de l'efficacit\u00e9 du traitement et du nombre de traitements trait\u00e9s auraient un impact significativement plus important que l'augmentation de l'efficacit\u00e9 du traitement seul. L'impact projet\u00e9 facilitera la pr\u00e9vision des maladies, la planification des ressources et les strat\u00e9gies de gestion du VHC. Un d\u00e9pistage et un diagnostic accrus seraient probablement n\u00e9cessaires dans le cadre d'une strat\u00e9gie nationale.<\/p>\n\n

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Lire le rapport complet<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Summary Background\/Aims Around 101,000 individuals are estimated to be viremic for chronic hepatitis C virus (HCV) in the Kingdom of Saudi Arabia (KSA) in 2014; however, only about 20% have been diagnosed. We aim to assess baseline epidemiology, disease burden, and evaluate strategies to eliminate HCV in KSA. Materials and Methods The infected population and […]<\/p>\n","protected":false},"author":24,"featured_media":3468,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[10],"publication-author":[655,1111,1110,1113,1112,1114,839,1109,1117,1115,1116,838,494,648,653],"class_list":["post-2596","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-hcv","publication-author-abaalkhail-f","publication-author-al-faleh-f","publication-author-al-ashgar-h","publication-author-al-hakeem-r","publication-author-al-swat-k","publication-author-alghamdi-a","publication-author-aljumah-aa","publication-author-alqutub-a","publication-author-altraif-i","publication-author-assiri-a","publication-author-babatin-m","publication-author-hashim-a","publication-author-razavi-h","publication-author-sanai-fm","publication-author-schmelzer-j"],"acf":[],"_links":{"self":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/2596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/comments?post=2596"}],"version-history":[{"count":5,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/2596\/revisions"}],"predecessor-version":[{"id":7576,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/2596\/revisions\/7576"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/media\/3468"}],"wp:attachment":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/media?parent=2596"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/categories?post=2596"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/tags?post=2596"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/publication-author?post=2596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}