{"id":2570,"date":"2016-12-16T16:46:00","date_gmt":"2016-12-16T16:46:00","guid":{"rendered":"https:\/\/cdafound.org\/?p=2570"},"modified":"2025-01-15T20:24:24","modified_gmt":"2025-01-15T20:24:24","slug":"global-prevalence-and-genotype-distribution-of-hepatitis-c-virus-infection-in-2015-a-modelling-study","status":"publish","type":"post","link":"https:\/\/cdafound.org\/fr\/global-prevalence-and-genotype-distribution-of-hepatitis-c-virus-infection-in-2015-a-modelling-study\/","title":{"rendered":"Pr\u00e9valence mondiale et distribution g\u00e9notypique de l'infection par le virus de l'h\u00e9patite C en 2015: une \u00e9tude de mod\u00e9lisation"},"content":{"rendered":"

R\u00e9sum\u00e9<\/h2>\n\n\n\n

Collaborateurs<\/h3>\n\n\n\n

Collaborateurs de l'Observatoire Polaris sur le VHC<\/strong>: Sarah Blach, Stefan Zeuzem, Michael Manns, Ibrahim Altraif, Ann-Sofi Duberg, David H Muljono, Imam Waked, Seyed M Alavian, Mei-Hsuan Lee, Francesco Negro, Faisal Abaalkhail, Ahmed Abdou, Maheeba Abdulla, Antoine Abou Rached, Inka Aho, Ulus Akarca, Imad Al Ghazzawi, Saad Al Kaabi, Faryal Al Lawati, Khalid Al Namaani, Youssif Al Serkal, Said A Al-Busafi, Layla Al-Dabal, Soo Aleman, Abdullah S Alghamdi, Abdulrahman A Aljumah, Hamad E Al-Romaihi, Monique I Andersson, Vic Arendt, Perttu Arkkila, Abdullah M Assiri, Oidov Baatarkhuu, Abate Bane, Ziv Ben-Ari, Colm Bergin, Fernando Bessone, Florian Bihl, Abdul R Bizri, Martin Blachier, Antonio J Blasco, Carlos E Brand\u00e3o Mello, Philip Bruggmann, Cheryl R Brunton, Filipe Calinas, Henry LY Chan, Asad Chaudhry, Hugo Cheinquer, Chien-Jen Chen, Rong-Nan Chien, Moon Seok Choi, Peer B Christensen, Wan-Long Chuang, Vladimir Chulanov, Laura Cisneros, Mette R Clausen, Matthew E Cramp, Antonio Craxi, Esther A Croes, Olav Dalgard, Jorge R Daruich, Victor de Ledinghen, Gregory J Dore, Manal H El-Sayed, Gul Erg\u00f6r, Gamal Esmat, Chris Estes, Karolin Falconer, Elmoubashar Farag, Maria LG Ferraz, Paulo R Ferreira, Robert Flisiak, Sona Frankova, Ivane Gamkrelidze, Ed Gane, Javier Garc\u00eda -Samaniego, Amir Ghafoor Khan, Ilias Gountas, Adrian Goldis, Magn\u00fas Gottfredsson, Jason Grebely, Michael Gschwantler, M\u00e1rio Guimar\u00e3es Pess\u00f4a, Jessie Gunter, Behzad Hajarizadeh, Omer Hajelssedig, Saeed Hamid, Waseemoudi Hofakis Haratt, Angelos Hajelssedig, Saeed Hamid, Waseemoudi Harattis Harald , Irena Hrstic, Yee-Tak Hui, Bela Hunyady, Ramazan Idilman, Wasim Jafri, Rohani Jahis, Naveed Z Janjua, Peter Jar\u010du\u0161ka, Agita Jeruma, J\u00f3n G Jonasson, Yasser Kamel, Jia-Horng Kao, Sabahattin Kaymakoglu, David Kawersadhen Khamis, Young S Kim, Loreta Kondili, Zaher Koutoubi, Mel Krajden, Henrik Krarup, Moon-Sing Lai, Wim Laleman, Wai-Cheung Lao, Daniel Lavanchy, Pablo L\u00e1zaro, Henri Leleu, Olufunmilayo Lesi, Laurentius A Lesmana, Michael Li, Valentina Liakina, Young-Suk Lim, Boris Luksic, Ada m Mahomed, Matti Maimets, Mih\u00e1ly Makara, Abraham O Malu, Rui T Marinho, Paul Marotta, Stefan Mauss, Muhammad S Memon, Maria C Mendes Correa, Nahum Mendez-Sanchez, Shahin Merat, Ammal M Metwally, Rosmawati Mohamed, Christophe Moreno, Fadi H Mourad, Beat M\u00fcllhaupt, Kimberly Murphy, Helen Nde, Richard Njouom, Diana Nonkovic, Suzanne Norris, Solomon Obekpa, Stephen Oguche, Sigur\u00f0ur Olafsson, Marian Oltman, Ogu Omede, Casimir Omuemu, Ohene Opare-Sem, Anne LH \u00d8vrehus, Shirley Owusu-Ofori, Tsendsuren S Oyunsuren, George Papatheodoridis, Ken Pasini, Kevork M Peltekian, Richard O Phillips, Nikolay Pimenov, Hossein Poustchi, Nishi Prabdial-Sing, Huma Qureshi, Alnoor Ramji, Devin Razavi-Shearer, Kathryn Razi-Shearer, Berryn Raz Redae, Henk W Reesink, Ezequiel Ridruejo, Sarah Robbins, Lewis R Roberts, Stuart K Roberts, William M Rosenberg, Fran\u00e7oise Roudot-Thoraval, Stephen D Ryder, Rifaat Safadi, Olga Sagalova, Riina Salupere, Faisal M Sanai, Juan F Sanchez Avila , Vivek Saraswat, Rui Sarmento-Cast ro, Christoph Sarrazin, Jonathan D Schmelzer, Ivan Schr\u00e9ter, Carole Seguin-Devaux, Samir R Shah, Ala I Sharara, Manik Sharma, Anatoly Shevaldin, Gamal E Shiha, William Sievert, Mark Sonderup, Kyriakos Souliotis, Danute Speiciene, Jan Sperl, Peter St\u00e4rkel, Rudolf E Stauber, Catherine Stedman, Daniel Struck, Tung-Hung Su, Vana Sypsa, Soek-Siam Tan, Junko Tanaka, Alexander J Thompson, Ieva Tolmane, Krzysztof Tomasiewicz, Jonas Valantinas, Pierre Van Damme, Adriaan J van der Meer, Ingo van Thiel, Hans Van Vlierberghe, Adriana Vince, Wolfgang Vogel, Heiner Wedemeyer, Nina Weis, Vincent Ws Wong, Cesar Yaghi, Ayman Yosry, Man-Fung Yuen, Evy Yunihastuti, Aasim Yusuf, Eli Zuckerman, Homie Razavi<\/p>\n\n\n\n

Arri\u00e8re-plan<\/h3>\n\n\n\n

La 69e Assembl\u00e9e mondiale de la Sant\u00e9 a approuv\u00e9 la Strat\u00e9gie mondiale du secteur de la sant\u00e9 pour \u00e9liminer l'infection par le virus de l'h\u00e9patite C (VHC) d'ici 2030, qui peut devenir une r\u00e9alit\u00e9 avec le lancement r\u00e9cent de th\u00e9rapies antivirales \u00e0 action directe. Des estimations fiables de la charge de morbidit\u00e9 sont n\u00e9cessaires pour les strat\u00e9gies nationales. Cette analyse estime la pr\u00e9valence mondiale du VHC vir\u00e9mique \u00e0 la fin de 2015, une mise \u00e0 jour et une extension de l'analyse de 2014, qui a signal\u00e9 80 millions d'infections vir\u00e9miques (95% CI 64-103) en 2013.<\/p>\n\n\n\n

M\u00e9thodes<\/h3>\n\n\n\n

Nous avons d\u00e9velopp\u00e9 des mod\u00e8les de charge de morbidit\u00e9 au niveau des pays \u00e0 la suite d'une revue syst\u00e9matique des \u00e9tudes de pr\u00e9valence du VHC (nombre d'\u00e9tudes, n = 6754) et de g\u00e9notype (n = 11 342) publi\u00e9es apr\u00e8s 2013. Un processus Delphi a \u00e9t\u00e9 utilis\u00e9 pour obtenir le consensus des experts nationaux et valider les contributions . Les seules estimations publi\u00e9es ont \u00e9t\u00e9 utilis\u00e9es pour les pays o\u00f9 les r\u00e9unions des groupes d'experts ne pouvaient pas \u00eatre programm\u00e9es. La pr\u00e9valence mondiale a \u00e9t\u00e9 estim\u00e9e \u00e0 l'aide des moyennes r\u00e9gionales des pays sans donn\u00e9es.<\/p>\n\n\n\n

R\u00e9sultats<\/h3>\n\n\n\n

Des mod\u00e8les ont \u00e9t\u00e9 \u00e9labor\u00e9s pour 100 pays, dont 59 ont \u00e9t\u00e9 approuv\u00e9s par des experts nationaux, les 41 autres \u00e9tant estim\u00e9s en utilisant uniquement les donn\u00e9es publi\u00e9es. Les autres pays ne disposaient pas de donn\u00e9es suffisantes pour cr\u00e9er un mod\u00e8le. La pr\u00e9valence mondiale du VHC vir\u00e9mique est estim\u00e9e \u00e0 1 \u00b7 0% (intervalle d'incertitude 95% 0 \u00b7 8-1 \u00b7 1) en 2015, ce qui correspond \u00e0 71 \u00b7 1 million (62 \u00b7 5-79 \u00b7 4) d'infections vir\u00e9miques. Les g\u00e9notypes 1 et 3 \u00e9taient la cause la plus fr\u00e9quente d'infections (44% et 25%, respectivement).<\/p>\n\n\n\n

Interpr\u00e9tation<\/h3>\n\n\n\n

L'estimation mondiale des infections vir\u00e9miques est inf\u00e9rieure aux estimations pr\u00e9c\u00e9dentes, en grande partie en raison d'estimations de pr\u00e9valence plus r\u00e9centes (plus faibles) en Afrique. En outre, une mortalit\u00e9 accrue due \u00e0 des causes li\u00e9es au foie et une population vieillissante peuvent avoir contribu\u00e9 \u00e0 une r\u00e9duction des infections.<\/p>\n\n\n\n

Financement<\/h3>\n\n\n\n

Fondation John C Martin.<\/p>\n\n

\n
Lire le rapport complet<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Summary Collaborators Polaris Observatory HCV Collaborators: Sarah Blach, Stefan Zeuzem, Michael Manns, Ibrahim Altraif, Ann-Sofi Duberg, David H Muljono, Imam Waked, Seyed M Alavian, Mei-Hsuan Lee, Francesco Negro, Faisal Abaalkhail, Ahmed Abdou, Maheeba Abdulla, Antoine Abou Rached, Inka Aho, Ulus Akarca, Imad Al Ghazzawi, Saad Al Kaabi, Faryal Al Lawati, Khalid Al Namaani, Youssif Al Serkal, Said A Al-Busafi, Layla Al-Dabal, Soo Aleman, Abdullah S Alghamdi, Abdulrahman A Aljumah, Hamad E Al-Romaihi, Monique I Andersson, Vic Arendt, Perttu Arkkila, Abdullah M Assiri, Oidov Baatarkhuu, Abate Bane, Ziv Ben-Ari, Colm Bergin, Fernando […]<\/p>\n","protected":false},"author":24,"featured_media":3216,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[10,12],"publication-author":[1080],"class_list":["post-2570","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-hcv","tag-modelling","publication-author-polaris-observatory-hcv-collaborators"],"acf":[],"_links":{"self":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/2570","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/comments?post=2570"}],"version-history":[{"count":6,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/2570\/revisions"}],"predecessor-version":[{"id":7571,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/2570\/revisions\/7571"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/media\/3216"}],"wp:attachment":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/media?parent=2570"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/categories?post=2570"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/tags?post=2570"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/publication-author?post=2570"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}