{"id":2558,"date":"2017-12-01T16:25:00","date_gmt":"2017-12-01T16:25:00","guid":{"rendered":"https:\/\/cdafound.org\/?p=2558"},"modified":"2025-01-15T03:18:03","modified_gmt":"2025-01-15T03:18:03","slug":"modeling-the-epidemic-of-nonalcoholic-fatty-liver-disease-demonstrates-an-exponential-increase-in-burden-of-disease","status":"publish","type":"post","link":"https:\/\/cdafound.org\/fr\/modeling-the-epidemic-of-nonalcoholic-fatty-liver-disease-demonstrates-an-exponential-increase-in-burden-of-disease\/","title":{"rendered":"La mod\u00e9lisation de l'\u00e9pid\u00e9mie de st\u00e9atose h\u00e9patique non alcoolique d\u00e9montre une augmentation exponentielle de la charge de morbidit\u00e9"},"content":{"rendered":"

R\u00e9sum\u00e9<\/h2>\n\n\n\n

La st\u00e9atose h\u00e9patique non alcoolique (NAFLD) et la st\u00e9atoh\u00e9patite non alcoolique (NASH) qui en r\u00e9sulte sont tr\u00e8s r\u00e9pandues aux \u00c9tats-Unis, o\u00f9 elles sont une cause croissante de cirrhose et de carcinome h\u00e9patocellulaire (CHC) et de plus en plus un indicateur de transplantation h\u00e9patique. Un mod\u00e8le de Markov a \u00e9t\u00e9 utilis\u00e9 pour pr\u00e9voir la progression de la maladie NAFLD. L'incidence de la NAFLD \u00e9tait bas\u00e9e sur les changements historiques et projet\u00e9s de la pr\u00e9valence chez l'adulte de l'ob\u00e9sit\u00e9 et du diab\u00e8te sucr\u00e9 de type 2 (DM). Les hypoth\u00e8ses ont \u00e9t\u00e9 tir\u00e9es de la litt\u00e9rature publi\u00e9e lorsque disponibles et valid\u00e9es \u00e0 l'aide des donn\u00e9es de surveillance nationales pour l'incidence du CHC li\u00e9 \u00e0 la NAFLD. Les changements projet\u00e9s dans la cirrhose li\u00e9e \u00e0 la NAFLD, la maladie h\u00e9patique avanc\u00e9e et la mortalit\u00e9 li\u00e9e au foie ont \u00e9t\u00e9 quantifi\u00e9s jusqu'en 2030. Les cas pr\u00e9valents de NAFLD devraient augmenter le 21%, passant de 83,1 millions (2015) \u00e0 100,9 millions (2030), tandis que les cas pr\u00e9valents de NASH augmenteront 63% de 16,52 millions \u00e0 27,00 millions de cas. La pr\u00e9valence globale de la NAFLD parmi la population adulte (\u00e2g\u00e9e = 15 ans) est projet\u00e9e \u00e0 33,51 TTP1T en 2030, et l'\u00e2ge m\u00e9dian de la population de la NAFLD augmentera de 50 \u00e0 55 ans entre 2015 et 2030. En 2015, environ 20% des cas de NAFLD ont \u00e9t\u00e9 class\u00e9s comme NASH, passant \u00e0 27% d'ici 2030, ce qui refl\u00e8te \u00e0 la fois la progression de la maladie et le vieillissement de la population. L'incidence de la cirrhose d\u00e9compens\u00e9e augmentera 168% \u00e0 105430 cas d'ici 2030, tandis que l'incidence du CHC augmentera de 137% \u00e0 12240 cas. Les d\u00e9c\u00e8s h\u00e9patiques augmenteront le 178% \u00e0 environ 78 300 d\u00e9c\u00e8s en 2030. Au cours de la p\u00e9riode 2015-2030, il devrait y avoir pr\u00e8s de 800 000 d\u00e9c\u00e8s h\u00e9patiques en exc\u00e8s. <\/p>\n\n\n\n

CONCLUSION<\/h3>\n\n\n\n

Avec des taux toujours \u00e9lev\u00e9s d'ob\u00e9sit\u00e9 et de diab\u00e8te chez les adultes et une population vieillissante, les maladies h\u00e9patiques et la mortalit\u00e9 li\u00e9es \u00e0 la NAFLD vont augmenter aux \u00c9tats-Unis. Des strat\u00e9gies pour ralentir la croissance des cas de NAFLD et des options th\u00e9rapeutiques sont n\u00e9cessaires pour att\u00e9nuer le fardeau de la maladie. (H\u00e9patologie 2018; 67: 123-133).<\/p>\n\n\n\n

Des pays:<\/strong> \u00c9tats Unis<\/p>\n\n

\n
Lire le rapport complet<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Summary Nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are highly prevalent in the United States, where they are a growing cause of cirrhosis and hepatocellular carcinoma (HCC) and increasingly an indicator for liver transplantation. A Markov model was used to forecast NAFLD disease progression. Incidence of NAFLD was based on historical and […]<\/p>\n","protected":false},"author":24,"featured_media":3479,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[12,24],"publication-author":[535,872,494,909,908],"class_list":["post-2558","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-modelling","tag-nafld","publication-author-estes-c","publication-author-loomba-r","publication-author-razavi-h","publication-author-sanyal-aj","publication-author-younossi-z"],"acf":[],"_links":{"self":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/2558","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/comments?post=2558"}],"version-history":[{"count":7,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/2558\/revisions"}],"predecessor-version":[{"id":7545,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/2558\/revisions\/7545"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/media\/3479"}],"wp:attachment":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/media?parent=2558"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/categories?post=2558"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/tags?post=2558"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/publication-author?post=2558"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}