Estimer la progression de l'\u00e9pid\u00e9mie de virus de l'h\u00e9patite C (VHC) et mesurer le fardeau de la morbidit\u00e9 et de la mortalit\u00e9 li\u00e9es au VHC.<\/p>\n\n\n\n
Des cohortes d\u00e9finies par l'\u00e2ge et le sexe ont \u00e9t\u00e9 utilis\u00e9es pour suivre la population vir\u00e9mique en Argentine et estimer l'incidence, la pr\u00e9valence, les complications h\u00e9patiques et la mortalit\u00e9 du VHC. L'impact relatif de deux sc\u00e9narios sur les r\u00e9sultats li\u00e9s au VHC a \u00e9t\u00e9 \u00e9valu\u00e9: (1) augmentation de la r\u00e9ponse virologique soutenue (RVS); et (2) augmentation de la RVS et du traitement.<\/p>\n\n\n\n
Dans le sc\u00e9nario 1, la RVS est pass\u00e9e \u00e0 85%-95% en 2016. Par rapport au sc\u00e9nario de base, il y avait une r\u00e9duction de 0,3% des cas pr\u00e9valents et des d\u00e9c\u00e8s li\u00e9s au foie d'ici 2030. Compte tenu des faibles taux de traitement, les cas de carcinome h\u00e9patocellulaire et de cirrhose d\u00e9compens\u00e9e ont diminu\u00e9 <1%, contrairement au cas de base en 2030. Dans le sc\u00e9nario 2, les m\u00eames augmentations de SVR ont \u00e9t\u00e9 mod\u00e9lis\u00e9es, avec des augmentations graduelles des populations annuelles diagnostiqu\u00e9es et trait\u00e9es. Ce sc\u00e9nario a r\u00e9duit les infections courantes 45%, les d\u00e9c\u00e8s li\u00e9s au foie 55%, les cas de cancer du foie 60% et la cirrhose d\u00e9compens\u00e9e 55%, par rapport au cas de base d'ici 2030.<\/p>\n\n\n\n
En Argentine, les cas de maladie h\u00e9patique terminale et de d\u00e9c\u00e8s li\u00e9s au foie dus au VHC continuent d'augmenter, tandis que sa pr\u00e9valence diminue. L'augmentation des taux de RVS ne suffit pas, et l'augmentation du nombre de patients diagnostiqu\u00e9s et de candidats au traitement est n\u00e9cessaire pour r\u00e9duire le fardeau de la maladie du VHC. Sur la base de ce sc\u00e9nario, des strat\u00e9gies visant \u00e0 accro\u00eetre le diagnostic et le recours au traitement doivent \u00eatre d\u00e9velopp\u00e9es pour r\u00e9duire la charge du VHC en Argentine.<\/p>\n\n\n\n
Des pays:<\/strong> Argentine<\/p>","protected":false},"excerpt":{"rendered":" Summary Aim To estimate the progression of the hepatitis C virus (HCV) epidemic and measure the burden of HCV-related morbidity and mortality. Methods Age- and gender-defined cohorts were used to follow the viremic population in Argentina and estimate HCV incidence, prevalence, hepatic complications, and mortality. The relative impact of two scenarios on HCV-related outcomes was […]<\/p>\n","protected":false},"author":24,"featured_media":3343,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[10],"publication-author":[1129,1130,535,1127,494,1128,1131,1126],"class_list":["post-2525","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-hcv","publication-author-bessone-f","publication-author-daruich-jr","publication-author-estes-c","publication-author-gadano-ac","publication-author-razavi-h","publication-author-ridruejo-e","publication-author-silva-mo","publication-author-villamil-fg"],"acf":[],"_links":{"self":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/2525","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/comments?post=2525"}],"version-history":[{"count":6,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/2525\/revisions"}],"predecessor-version":[{"id":7580,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/posts\/2525\/revisions\/7580"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/media\/3343"}],"wp:attachment":[{"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/media?parent=2525"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/categories?post=2525"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/tags?post=2525"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/cdafound.org\/fr\/wp-json\/wp\/v2\/publication-author?post=2525"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}