{"id":2628,"date":"2015-08-24T20:05:00","date_gmt":"2015-08-24T20:05:00","guid":{"rendered":"https:\/\/cdafound.org\/?p=2628"},"modified":"2025-01-16T15:31:05","modified_gmt":"2025-01-16T15:31:05","slug":"interferon-based-hepatitis-c-antiviral-treatment-outcomes-may-be-predicted-by-alanine-aminotransferase-levels","status":"publish","type":"post","link":"https:\/\/cdafound.org\/es\/interferon-based-hepatitis-c-antiviral-treatment-outcomes-may-be-predicted-by-alanine-aminotransferase-levels\/","title":{"rendered":"Los resultados del tratamiento antiv\u00edrico de la hepatitis C basado en interfer\u00f3n pueden predecirse mediante los niveles de alanina aminotransferasa"},"content":{"rendered":"<h2 class=\"wp-block-heading\">Resumen<\/h2>\n\n\n\n<p>A menudo se observa una disminuci\u00f3n o normalizaci\u00f3n de los niveles de enzimas hep\u00e1ticas despu\u00e9s del inicio del tratamiento antiviral contra el virus de la hepatitis C (VHC) basado en interfer\u00f3n y puede reflejar la respuesta a la terapia y la disminuci\u00f3n de los niveles de ARN del VHC (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4699597\/#b1-cjgh-29-407\">1<\/a>,<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4699597\/#b2-cjgh-29-407\">2<\/a>). La elevaci\u00f3n del nivel de alanina aminotransferasa (ALT) durante el tratamiento puede estar asociada con viremia persistente (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4699597\/#b3-cjgh-29-407\">3<\/a>\u2013<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4699597\/#b5-cjgh-29-407\">5<\/a>). No est\u00e1 claro el valor de la respuesta enzim\u00e1tica para predecir la respuesta virol\u00f3gica sostenida (RVS) y la reca\u00edda.<\/p>\n\n\n\n<p>Evaluamos el papel de los niveles basales y en la semana 4 de ALT y aspartato aminotransferasa (AST) en la predicci\u00f3n de la respuesta del VHC a la terapia antiviral basada en interfer\u00f3n. Se realiz\u00f3 un an\u00e1lisis retrospectivo de la base de datos de 434 adultos con VHC que iniciaron la terapia en la Cl\u00ednica de Hepatitis Virales del Hospital de Ottawa (Ottawa, Ontario) entre el 1 de enero de 2000 y el 31 de diciembre de 2009 (n\u00famero del Comit\u00e9 de \u00c9tica de Investigaci\u00f3n 2004-196).<\/p>\n\n\n\n<p><strong>Pa\u00edses:<\/strong> Canad\u00e1<\/p>\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link has-text-color wp-element-button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4699597\/\" target=\"_blank\" rel=\"noreferrer noopener\">Lea el informe completo<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Summary On-therapy decline or normalization of liver enzyme levels is often observed following initiation of interferon-based hepatitis C virus (HCV) antiviral treatment and may reflect response to therapy and decreasing HCV RNA levels (1,2). On-treatment alanine aminotransferase (ALT) level elevation may be associated with persistent viremia (3\u20135). The value of enzymatic response in predicting sustained [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":3295,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[10],"publication-author":[488,1386,2087,494],"class_list":["post-2628","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-hcv","publication-author-blach-s","publication-author-cooper-c","publication-author-kelly-e","publication-author-razavi-h"],"acf":[],"_links":{"self":[{"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/posts\/2628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/comments?post=2628"}],"version-history":[{"count":7,"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/posts\/2628\/revisions"}],"predecessor-version":[{"id":7601,"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/posts\/2628\/revisions\/7601"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/media\/3295"}],"wp:attachment":[{"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/media?parent=2628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/categories?post=2628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/tags?post=2628"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/publication-author?post=2628"}],"curies":[{"name":"gracias","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}