{"id":2118,"date":"2020-05-20T20:12:35","date_gmt":"2020-05-20T20:12:35","guid":{"rendered":"https:\/\/cdafound.org\/?page_id=2118"},"modified":"2025-08-01T18:06:58","modified_gmt":"2025-08-01T18:06:58","slug":"uhep-innovation","status":"publish","type":"page","link":"https:\/\/cdafound.org\/es\/uhep-innovation\/","title":{"rendered":"Innovaciones y optimizaciones: reducci\u00f3n de costos, aumento de la vinculaci\u00f3n con la atenci\u00f3n"},"content":{"rendered":"\n<p class=\"has-h-6-font-size wp-block-paragraph\">Although scalable and sustainable funding of hepatitis elimination is the primary objective of the UHEP project, we are introducing numerous other innovations to reduce or eliminate financial and non-financial barriers across the entire continuum of care. The innovations will simplify testing and treatment, make services more accessible and convenient, reduce elimination costs and improve linkage and adherence rates.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">UHEP Innovations Include<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\">\n<h3 class=\"wp-block-heading\">Catalytic Funding<\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:75%\">\n<p class=\"wp-block-paragraph\">UHEP will use catalytic funding to reduce the amount of upfront capital required for an elimination program and will rely on patient payments to cover all program costs including repayment of the initial catalytic investment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CDAF modeling shows that a national elimination program in Uzbekistan could be paid for with a $27M USD catalytic investment, which would pay for a $522M USD program and would be repaid at the end of the program, yielding a catalytic ratio of 19.3.<\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\">\n<h3 class=\"wp-block-heading\">Pooled Procurement<\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:75%\">\n<p class=\"wp-block-paragraph\">UHEP will use of a pooled procurement mechanism (GPRO) to source affordable, quality-assured diagnostics and medicines at prices affordable to LMIC patients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">GPRO is a non-profit procurement agency. It negotiates volume pricing directly with manufacturers to reduce costs. GPRO charges 5% of the total order amount to cover administrative costs. No additional markups are added. GPRO does not use distributors \u2013 it ships product directly to the purchasing agency. GPRO requires registration and agreement by the purchasing agency to mark up prices a maximum of 5%.<\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\">\n<h3 class=\"wp-block-heading\">Negotiated Pricing<\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:75%\">\n<p class=\"wp-block-paragraph\">CDAF has negotiated the waiving of import duties and taxes for UHEP medicines and diagnostics. We have also signed a formal agreement with a national pharmacy chain (OxyMED) to distribute UHEP medicines with a maximum 5% markup.<\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\">\n<h3 class=\"wp-block-heading\">Simplified Test &amp; Treat<\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:75%\">\n<p class=\"wp-block-paragraph\">UHEP will utilize simplified diagnostic algorithms for HBV and HCV to reduce program costs and improve linkage to care.<\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\">\n<h3 class=\"wp-block-heading\">Task-Sharing<\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:75%\">\n<p class=\"wp-block-paragraph\">Today in Uzbekistan, all hepatitis patients receive care by liver specialists at the Research Institute of Virology. For UHEP testing will take place at district Polyclinics throughout Tashkent and most patients will be treated by General Practitioners at the Polyclinic. Patients with complications or liver disease will be referred to the RIV specialists.<\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\">\n<h3 class=\"wp-block-heading\">Motivational Interviews<\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:75%\">\n<p class=\"wp-block-paragraph\">A Motivational Interview technique used successfully in other treatment-oriented programs has been designed to engage patients immediately following a positive screening test, and though a series of short questions help raise awareness of the risks of hepatitis while driving internal motivation to seek and adhere to treatment.<\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\">\n<h3 class=\"wp-block-heading\">Electronic Registry<\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:75%\">\n<p class=\"wp-block-paragraph\">UHEP customized a REDCAP electronic patient registry to collect and manage patient consent and patient medical data, and also to facilitate followup with patients who unlink from care. Portable tablets and laptops have been provided to all nurses and doctors to enable near real-time updates of patient records.<\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">KPIs<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Measuring Outcomes<\/h3>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"900\" height=\"621\" src=\"https:\/\/cdafound.org\/wp-content\/uploads\/2025\/01\/04_optimizations.jpg\" alt=\"\" class=\"wp-image-7324\" style=\"width:474px\" srcset=\"https:\/\/cdafound.org\/wp-content\/uploads\/2025\/01\/04_optimizations.jpg 900w, https:\/\/cdafound.org\/wp-content\/uploads\/2025\/01\/04_optimizations-300x207.jpg 300w, https:\/\/cdafound.org\/wp-content\/uploads\/2025\/01\/04_optimizations-768x530.jpg 768w, https:\/\/cdafound.org\/wp-content\/uploads\/2025\/01\/04_optimizations-18x12.jpg 18w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Key Performance Indicators and Minimum [Expected] Success Criteria<\/h3>\n\n\n<dl class=\"wp-block-polaris-dl\" id=\"polaris-dl-1\" data-group=\"polaris-dl-1\"><div class=\"wp-block-polaris-sections-entry\" id=\"polaris-sections-entry-1-0\" data-group=\"polaris-dl-1\"><dt class=\"wp-block-polaris-sections-entry-heading\" >Large scale general population hepatitis screening is feasible with rapid HBV and HCV diagnostic tests<\/dt><dd class=\"wp-block-polaris-sections-entry-content\"><p class=\"wp-block-paragraph\">Minimum and [Expected] success criteria: Screen 125,000 [250,000] adults with HCV &amp; HBV RDT in the general population for HCV and HBV over 1 year.<\/p><\/dd><\/div><div class=\"wp-block-polaris-sections-entry\" id=\"polaris-sections-entry-1-1\" data-group=\"polaris-dl-1\"><dt class=\"wp-block-polaris-sections-entry-heading\" >A streamlined blood collection program will result in a high percentage of confirmed HCV testing rates among those found to be HCV antibody positive<\/dt><dd class=\"wp-block-polaris-sections-entry-content\"><p class=\"wp-block-paragraph\">Minimum and [Expected] success criteria: 80% [95%] of all who are anti-HCV+ will agree to give blood to be tested for HCV core antigen.<\/p><\/dd><\/div><div class=\"wp-block-polaris-sections-entry\" id=\"polaris-sections-entry-1-2\" data-group=\"polaris-dl-1\"><dt class=\"wp-block-polaris-sections-entry-heading\" >With a low-cost treatment option and motivational interviewing, a high percentage of chronic HCV and HBV patients will choose to be treated as part of this program<\/dt><dd class=\"wp-block-polaris-sections-entry-content\"><p class=\"wp-block-paragraph\">Minimum and [Expected] success criteria: 55% [80%] of all diagnosed chronic HCV and HBV patients go on treatment.<\/p><\/dd><\/div><div class=\"wp-block-polaris-sections-entry\" id=\"polaris-sections-entry-1-3\" data-group=\"polaris-dl-1\"><dt class=\"wp-block-polaris-sections-entry-heading\" >With patient education, HBV patients will stay on chronic treatment<\/dt><dd class=\"wp-block-polaris-sections-entry-content\"><p class=\"wp-block-paragraph\">Minimum and [Expected] success criteria: 75% [95%] of patients starting HBV treatment will remain on treatment after 1 year.<\/p><\/dd><\/div><div class=\"wp-block-polaris-sections-entry\" id=\"polaris-sections-entry-1-4\" data-group=\"polaris-dl-1\"><dt class=\"wp-block-polaris-sections-entry-heading\" >With patient education and reminders, patients will have a high refill ratio<\/dt><dd class=\"wp-block-polaris-sections-entry-content\"><p class=\"wp-block-paragraph\">Minimum and [Expected] success criteria: 75% [90%] of all HCV &amp; HBV patients will refill their Rx within 10 days.<\/p><\/dd><\/div><div class=\"wp-block-polaris-sections-entry\" id=\"polaris-sections-entry-1-5\" data-group=\"polaris-dl-1\"><dt class=\"wp-block-polaris-sections-entry-heading\" >With patient education and reminders, HCV patients will come back for their SVR12, and HBV patients will come back for their annual tests<\/dt><dd class=\"wp-block-polaris-sections-entry-content\"><p class=\"wp-block-paragraph\">Minimum and [Expected] success criteria: 70% [85%] of all HCV &amp; HBV patients on treatment.<\/p><\/dd><\/div><div class=\"wp-block-polaris-sections-entry\" id=\"polaris-sections-entry-1-6\" data-group=\"polaris-dl-1\"><dt class=\"wp-block-polaris-sections-entry-heading\" >A catalytic funding mechanism can be used to finance hepatitis elimination programs without need for massive donations or grants<\/dt><dd class=\"wp-block-polaris-sections-entry-content\"><p class=\"wp-block-paragraph\">Minimum and [Expected] success criteria:&nbsp; 80% [100%] of the initial catalytic investment is paid back at the end of the pilot program.<\/p><\/dd><\/div><\/dl>","protected":false},"excerpt":{"rendered":"<p>Although scalable and sustainable funding of hepatitis elimination is the primary objective of the UHEP project, we are introducing numerous other innovations to reduce or eliminate financial and non-financial barriers across the entire continuum of care. The innovations will simplify testing and treatment, make services more accessible and convenient, reduce elimination costs and improve linkage [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":7323,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"subtheme":[],"class_list":["post-2118","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/pages\/2118","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/comments?post=2118"}],"version-history":[{"count":9,"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/pages\/2118\/revisions"}],"predecessor-version":[{"id":8361,"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/pages\/2118\/revisions\/8361"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/media\/7323"}],"wp:attachment":[{"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/media?parent=2118"}],"wp:term":[{"taxonomy":"subtheme","embeddable":true,"href":"https:\/\/cdafound.org\/es\/wp-json\/wp\/v2\/subtheme?post=2118"}],"curies":[{"name":"gracias","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}