{"id":9163,"date":"2026-01-01T06:12:00","date_gmt":"2026-01-01T06:12:00","guid":{"rendered":"https:\/\/cdafound.org\/?p=9163"},"modified":"2026-05-31T17:05:45","modified_gmt":"2026-05-31T17:05:45","slug":"bulevirtide-for-chronic-hepatitis-delta-from-clinical-trials-to-real-life-data-an-expert-opinion-report","status":"publish","type":"post","link":"https:\/\/cdafound.org\/ar\/bulevirtide-for-chronic-hepatitis-delta-from-clinical-trials-to-real-life-data-an-expert-opinion-report\/","title":{"rendered":"\u0628\u0648\u0644\u064a\u0641\u064a\u0631\u062a\u064a\u062f \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u062f\u0644\u062a\u0627 \u0627\u0644\u0645\u0632\u0645\u0646: \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0625\u0644\u0649 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062d\u064a\u0627\u0629 \u0627\u0644\u0648\u0627\u0642\u0639\u064a\u0629: \u062a\u0642\u0631\u064a\u0631 \u0631\u0623\u064a \u0627\u0644\u062e\u0628\u0631\u0627\u0621"},"content":{"rendered":"<h2 class=\"wp-block-heading\">\u0645\u0644\u062e\u0635<\/h2>\n\n\n\n<p>\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u062f (HDV) \u0647\u0648 \u0641\u064a\u0631\u0648\u0633 \u0635\u063a\u064a\u0631 \u0645\u0646 \u0646\u0648\u0639 RNA\u060c \u0648\u064a\u062a\u0637\u0644\u0628 \u0648\u062c\u0648\u062f \u0645\u0633\u062a\u0636\u062f \u0633\u0637\u062d \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u0628 (HBsAg) \u0644\u062a\u0643\u0648\u064a\u0646 \u063a\u0644\u0627\u0641\u0647. \u062a\u0645 \u0648\u0635\u0641 \u062b\u0645\u0627\u0646\u064a\u0629 \u0623\u0646\u0645\u0627\u0637 \u062c\u064a\u0646\u064a\u0629\u060c \u062a\u062a\u0634\u0627\u0631\u0643 \u0641\u064a \u0623\u0643\u062b\u0631 \u0645\u0646 80 \u062a\u0633\u0644\u0633\u0644\u064b\u0627 \u0645\u062a\u0645\u0627\u062b\u0644\u064b\u0627\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u0641\u0631\u0639\u064a\u0629. \u064a\u064f\u0642\u062f\u0651\u0631 \u0627\u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0639\u0627\u0644\u0645\u064a \u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u062f \u0627\u0644\u0645\u0632\u0645\u0646 (CHD) \u0628\u0646\u062d\u0648 5 \u0623\u0636\u0639\u0627\u0641 \u062d\u0627\u0644\u0627\u062a \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u0628 \u0627\u0644\u0645\u0632\u0645\u0646\u060c \u0623\u064a \u0645\u0627 \u064a\u0639\u0627\u062f\u0644 15-20 \u0645\u0644\u064a\u0648\u0646 \u0634\u062e\u0635. \u064a\u0639\u062a\u0645\u062f \u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u062f \u0639\u0644\u0649 \u0648\u062c\u0648\u062f \u0623\u062c\u0633\u0627\u0645 \u0645\u0636\u0627\u062f\u0629 \u0644\u0645\u0633\u062a\u0636\u062f \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u062f (\u0623\u062c\u0633\u0627\u0645 \u0645\u0636\u0627\u062f\u0629 \u0644\u0640 HDV). \u064a\u0634\u064a\u0631 \u0648\u062c\u0648\u062f \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0627\u0644\u0643\u0644\u064a\u0629 \u0644\u0640 HDV \u0625\u0644\u0649 \u0627\u0644\u062a\u0639\u0631\u0636 \u0644\u0644\u0641\u064a\u0631\u0648\u0633 (\u0648\u0644\u064a\u0633 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0647). \u0644\u062a\u0623\u0643\u064a\u062f \u0627\u0644\u0625\u0635\u0627\u0628\u0629\u060c \u064a\u062e\u0636\u0639 \u0627\u0644\u0645\u0631\u064a\u0636 \u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0628\u0648\u0644\u064a\u0645\u064a\u0631\u0627\u0632 \u0627\u0644\u0645\u062a\u0633\u0644\u0633\u0644 (PCR)\u060c \u0648\u0644\u0627 \u064a\u062a\u0645 \u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u062f \u0625\u0644\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0625\u064a\u062c\u0627\u0628\u064a\u0629. \u064a\u062c\u0628 \u0625\u062c\u0631\u0627\u0621 \u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u062c\u0645\u064a\u0639 \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0630\u064a\u0646 \u062a\u0643\u0648\u0646 \u0646\u062a\u064a\u062c\u0629 \u0627\u062e\u062a\u0628\u0627\u0631 HBsAg \u0644\u062f\u064a\u0647\u0645 \u0625\u064a\u062c\u0627\u0628\u064a\u0629. \u064a\u064f\u0639\u062f \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u062f \u0627\u0644\u0645\u0632\u0645\u0646 \u0623\u0643\u062b\u0631 \u062d\u062f\u0629 \u0648\u062a\u0637\u0648\u0631\u064b\u0627 \u0645\u0646 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u0628 \u0641\u0642\u0637\u060c \u0645\u0639 \u0627\u0631\u062a\u0641\u0627\u0639 \u062e\u0637\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u062a\u0644\u064a\u0641 \u0627\u0644\u0643\u0628\u062f \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0643\u0628\u062f\u064a\u0629\u060c \u0648\u0632\u0631\u0627\u0639\u0629 \u0627\u0644\u0643\u0628\u062f\u060c \u0648\u0627\u0644\u0648\u0641\u0627\u0629. \u0627\u0633\u062a\u064f\u062e\u062f\u0645 \u0627\u0644\u0625\u0646\u062a\u0631\u0641\u064a\u0631\u0648\u0646 \u0623\u0644\u0641\u0627 \u0627\u0644\u0645\u064f\u0628\u064e\u063a\u0652\u0644\u064e\u062c (pegIFN-\u03b1) \u0644\u0639\u0644\u0627\u062c \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0643\u0628\u062f \u0627\u0644\u0645\u0632\u0645\u0646\u0629\u060c \u0644\u0643\u0646 \u0627\u0633\u062a\u062c\u0627\u0628\u062a\u0647 \u0637\u0648\u064a\u0644\u0629 \u0627\u0644\u0623\u0645\u062f \u0643\u0627\u0646\u062a \u0645\u062d\u062f\u0648\u062f\u0629. \u064a\u064f\u062b\u0628\u0650\u0651\u0637 \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u062d\u0642\u0646 pegIFN-\u03b1 \u062a\u062d\u062a \u0627\u0644\u062c\u0644\u062f \u0623\u0633\u0628\u0648\u0639\u064a\u064b\u0627 \u0644\u0645\u062f\u0629 48 \u0623\u0633\u0628\u0648\u0639\u064b\u0627 \u062a\u0643\u0627\u062b\u0631 \u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u062f\u0644\u062a\u0627 (HDV) \u0644\u062f\u0649 \u0645\u0627 \u064a\u0642\u0627\u0631\u0628 20-30 \u0645\u0631\u064a\u0636\u064b\u0627 \u0628\u0639\u062f 24 \u0623\u0633\u0628\u0648\u0639\u064b\u0627 \u0645\u0646 \u0625\u064a\u0642\u0627\u0641 \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u0645\u0639 \u0622\u062b\u0627\u0631 \u062c\u0627\u0646\u0628\u064a\u0629 \u0645\u0644\u062d\u0648\u0638\u0629. \u0648\u0642\u062f \u0648\u0627\u0641\u0642\u062a \u0648\u0643\u0627\u0644\u0629 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 (EMA) \u0639\u0644\u0649 \u062f\u0648\u0627\u0621 \u0628\u0648\u0644\u064a\u0641\u064a\u0631\u062a\u064a\u062f (BLV) \u0641\u064a \u0639\u0627\u0645 2020 \u0644\u0639\u0644\u0627\u062c \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0643\u0628\u062f \u0627\u0644\u0645\u0632\u0645\u0646\u0629 \u0648\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0643\u0628\u062f \u0627\u0644\u0645\u064f\u0639\u0627\u0648\u0636\u0629. \u0648\u0645\u0646\u0630 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u064a\u0647\u060c \u062a\u0631\u0627\u0643\u0645\u062a \u0628\u064a\u0627\u0646\u0627\u062a \u0648\u0627\u0642\u0639\u064a\u0629 \u062d\u0648\u0644 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 BLV\u060c \u062d\u064a\u062b \u0643\u0627\u0646 \u0645\u0639\u0638\u0645 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u064f\u0639\u0627\u0644\u064e\u062c\u064a\u0646 \u0641\u064a \u0623\u0648\u0631\u0648\u0628\u0627 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u062a\u0644\u064a\u0641 \u0643\u0628\u062f\u064a \u0645\u062a\u0642\u062f\u0645 \u0623\u0648 \u062a\u0634\u0645\u0639. \u0648\u062a\u062a\u0648\u0627\u0641\u0642 \u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0648\u0627\u0642\u0639\u064a\u0629 \u0645\u0639 \u0645\u0627 \u0644\u0648\u062d\u0638 \u0641\u064a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629\u060c \u062d\u064a\u062b \u062d\u0642\u0642 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0646\u062e\u0641\u0627\u0636\u0627\u062a \u0643\u0628\u064a\u0631\u0629 \u0641\u064a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u064a (RNA) \u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u062f\u0644\u062a\u0627 (HDV) \u0648\u062a\u0637\u0628\u064a\u0639 \u0625\u0646\u0632\u064a\u0645 \u0646\u0627\u0642\u0644\u0629 \u0623\u0645\u064a\u0646 \u0627\u0644\u0623\u0644\u0627\u0646\u064a\u0646 (ALT) \u0628\u0639\u062f \u0639\u062f\u0629 \u0623\u0634\u0647\u0631 \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0633\u0644\u0627\u0645\u0629 \u062c\u064a\u062f\u0629. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0641\u0625\u0646 \u0627\u062e\u062a\u0641\u0627\u0621 \u0645\u0633\u062a\u0636\u062f \u0633\u0637\u062d \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u0628 (HBsAg) \u0646\u0627\u062f\u0631 \u0646\u0633\u0628\u064a\u064b\u0627. \u064a\u0624\u062f\u064a \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u062d\u062f\u0648\u062f \u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0628\u064a\u0636\u0627\u0636 \u0627\u0644\u062f\u0645 \u0627\u0644\u0628\u0642\u0631\u064a\u060c \u0628\u0627\u0644\u0627\u0634\u062a\u0631\u0627\u0643 \u0645\u0639 \u0627\u0644\u0625\u0646\u062a\u0631\u0641\u064a\u0631\u0648\u0646 \u0623\u0644\u0641\u0627 \u0627\u0644\u0645\u064f\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0628\u0648\u0644\u064a \u0625\u064a\u062b\u064a\u0644\u064a\u0646 \u062c\u0644\u064a\u0643\u0648\u0644\u060c \u0625\u0644\u0649 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0637\u0648\u064a\u0644\u0629 \u0627\u0644\u0623\u0645\u062f \u0645\u0644\u062d\u0648\u0638\u0629\u060c \u062d\u064a\u062b \u062d\u0642\u0642 \u0623\u0643\u062b\u0631 \u0645\u0646 30% \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0643\u0627\u0645\u0644\u0629 (%) \u0648\u0627\u062e\u062a\u0641\u0627\u0621\u064b \u062a\u0627\u0645\u064b\u0627 \u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0643\u0628\u062f \u062f\u0644\u062a\u0627 \u0628\u0639\u062f \u0625\u064a\u0642\u0627\u0641 \u0627\u0644\u0639\u0644\u0627\u062c. \u0646\u062d\u0646 \u0628\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0639\u0644\u0627\u062c\u0627\u062a \u0645\u062d\u062f\u0648\u062f\u0629 \u062c\u062f\u064a\u062f\u0629. \u064a\u0644\u0632\u0645 \u062a\u0648\u0641\u064a\u0631 \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0648\u0627\u0642\u0639\u064a\u0629 \u0648\u0639\u0644\u0627\u062c\u0627\u062a \u0623\u062d\u062f\u062b \u0644\u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 \u0627\u0644\u062e\u0637\u064a\u0631.<\/p>\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link has-text-color wp-element-button\" href=\"https:\/\/cdafound.org\/wp-content\/uploads\/2026\/05\/Asselah-2025-Bulevirtide-for-chronic-hepatitis-delta.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u0627\u0642\u0631\u0623 \u0627\u0644\u062a\u0642\u0631\u064a\u0631 \u0627\u0644\u0643\u0627\u0645\u0644<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Summary Hepatitis D virus (HDV) is a small RNA virus that requires Hepatitis B Surface Antigen (HBsAg) for its envelope. Eight genotypes with more than 80 % sequence homology and many subgenotypes have been described. Worldwide prevalence of chronic hepatitis delta (CHD) is estimated at about 5 % of chronic hepatitis B cases, translating to [&hellip;]<\/p>\n","protected":false},"author":939,"featured_media":9177,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[2748,2747,21,58],"publication-author":[2750,97,2751,2749],"class_list":["post-9163","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-drug-development","tag-ema","tag-hbv","tag-hdv","publication-author-helene-fontaine","publication-author-homie-razavi","publication-author-kosh-agarwal","publication-author-tarik-asselah"],"acf":[],"_links":{"self":[{"href":"https:\/\/cdafound.org\/ar\/wp-json\/wp\/v2\/posts\/9163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdafound.org\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdafound.org\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdafound.org\/ar\/wp-json\/wp\/v2\/users\/939"}],"replies":[{"embeddable":true,"href":"https:\/\/cdafound.org\/ar\/wp-json\/wp\/v2\/comments?post=9163"}],"version-history":[{"count":1,"href":"https:\/\/cdafound.org\/ar\/wp-json\/wp\/v2\/posts\/9163\/revisions"}],"predecessor-version":[{"id":9165,"href":"https:\/\/cdafound.org\/ar\/wp-json\/wp\/v2\/posts\/9163\/revisions\/9165"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdafound.org\/ar\/wp-json\/wp\/v2\/media\/9177"}],"wp:attachment":[{"href":"https:\/\/cdafound.org\/ar\/wp-json\/wp\/v2\/media?parent=9163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdafound.org\/ar\/wp-json\/wp\/v2\/categories?post=9163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdafound.org\/ar\/wp-json\/wp\/v2\/tags?post=9163"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/cdafound.org\/ar\/wp-json\/wp\/v2\/publication-author?post=9163"}],"curies":[{"name":"\u0648\u0648\u0631\u062f\u0628\u0631\u064a\u0633","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}